在基于JAMAR的临床访问期间,何时应应对青少年异常性关节炎的疲劳
Anouk Vroegindeweij1, Sabine Musterd2, Sanne Nijhof1,3
1Department of Social Pediatrics, Wilhelmina Children's Hospital, University Medical Center Utrecht, Utrecht University, Utrecht, The Netherlands.
Rheumatology (Oxford, England)
|June 9, 2025
概括
青春期异形性关节炎 (JIA) 患者经常经历疲劳. 使用来自少年关节炎多维评估报告 (JAMAR) 的生活质量项目的新代理可以帮助识别需要疲劳评估的患者.
科学领域:
- 儿科风湿病学 儿科风湿病学
- 临床评估工具 临床评估工具
- 患者报告的结果
背景情况:
- 疲劳是青少年异常性关节炎 (JIA) 中常见但未被认可的症状.
- 广泛使用的少年关节炎多维评估报告 (JAMAR) 缺乏具体的疲劳评估项目.
- 需要实用工具来识别在临床环境中出现显著疲劳的JIA患者.
研究的目的:
- 评估JAMAR中的特定生活质量 (QoL) 项目是否可以作为JIA患者疲劳评估的代理.
- 为了确定这种代理用于识别严重疲劳的预测值和最佳截止分数.
- 促使临床医生在例行JIA临床访问期间解决疲劳问题.
主要方法:
- 105名JIA患者完成了JAMAR和个人力量-8 (CIS-8) 检查清单,以进行严重疲劳评估.
- 相关性分析确定了QOL项目3 (耗能活动) 和9 (度) 作为疲劳最强的预测因素.
- 二元物流回归和ROC分析确定了代理的预测准确性和切断点数.
主要成果:
- 质量标准第3项和第9项与严重疲劳有很强的相关性 (分别r=0.644和r=0.555).
- 这两个项目的总得分 (代理) 显著预测了严重疲劳 (AUC=0.911,灵敏度=90%,特异性=69.6%在切断时≥1).
- 代理表明,在两个队列 (WCH和EPOCA) 中,超过56%的患者应该解决疲劳问题.
结论:
- 使用两个JAMAR QoL项目的简单代理可以有效地估计JIA患者疲劳评估的需要.
- 这种代理可以帮助临床医生识别需要进一步评估疲劳的患者.
- 对于精确测量疲劳严重程度,建议使用像CIS-8这样的验证问卷.
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