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儿童肥胖对成年人静脉血栓栓塞的因果影响:双向的门德尔随机化研究

Jintuo Zhou¹, Meiling Wu², Yongjin Xie³

¹Department of Pharmacy, Fujian Maternity and Child Health Hospital College of Clinical Medicine for Obstetrics and Gynecology and Pediatrics, Fujian Medical University, Fuzhou, China.

|June 9, 2025

概括

儿童肥胖症显著增加了成人静脉血栓塞栓症 (VTE) 的风险. 这项遗传研究没有发现VTE导致儿童肥胖的证据,强调了早期体重管理的重要性.

科学领域:

遗传学是一个遗传学.
流行病学流行病学
公共卫生公共卫生

背景情况:

肥胖是已知的静脉血栓塞栓症 (VTE) 的风险因素.
儿童肥胖和成年人VTE风险之间的因果关系尚不清楚.
遗传研究可以帮助阐明因果关系.

研究的目的:

通过双向门德尔随机化分析,研究儿童肥胖和成人VTE风险之间的因果关系.
为了确定成年期的VTE是否会影响儿童肥胖.
探索儿童体重指数 (BMI) 和VTE之间的遗传相关性.

主要方法:

双向的双样本孟德尔随机化 (MR) 分析.
全基因组关联研究 (GWAS) 数据.
逆变量加权 (IVW),加权中位数,MR-Egger和链接不平衡得分回归 (LDSC) 方法.
敏感性分析包括Cochran Q,MR-Egger拦截,MR-PRESSO和留出一个的分析.

主要成果:

儿童BMI对成年人VTE,肺栓塞 (PE) 和深静脉血栓 (DVT) 有显著的因果作用.
没有发现反向因果关系的证据;VTE没有因果影响儿童肥胖.
在儿童BMI和成人VTE结局之间观察到显著的遗传相关性.

结论:

儿童肥胖是成年人发展VTE的重要危险因素.
早期预防和体重管理策略对于降低VTE风险至关重要.
需要进一步的研究来了解生物机制和干预措施的影响.

关键词:

门德尔的随机化分析.儿童肥胖儿童肥胖儿童肥胖深静脉血栓形成的原因是深静脉血栓形成.肺栓塞肺栓塞是一种肺栓塞.静脉血栓塞栓症是一种静脉血栓塞栓.

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