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围产阶段瘦素对下丘脑大脑衍生的神经营养因子的影响以及与能量平衡相关的基因调节

Ana María Rodríguez¹, Madhu Asnani-Kishnani², Zhi Xin Yau-Qiu¹

¹Laboratory of Molecular Biology, Nutrition and Biotechnology (Group of Nutrigenomics, Biomarkers and Risk Evaluation-NuBE), University of the Balearic Islands (UIB), Palma, Spain; Health Research Institute of the Balearic Islands (IdISBa), Palma, Spain; CIBER of Physiopathology of Obesity and Nutrition (CIBEROBN), Instituto de Salud Carlos III, Madrid, Spain.

The Journal of nutritional biochemistry

|June 9, 2025

概括

哺乳期服用瘦素补充剂会影响大脑基因表达,影响能量平衡和瘦肉量. 这种代谢印记显示了取决于性别的效应,女性从这种早期的干预中受益更多.

科学领域:

神经科学是一个神经科学.
代谢调节代谢调节代谢调节代谢调节
发展生物学发展生物学

背景情况:

大脑衍生神经营养因子 (BDNF) 和瘦素对神经发育和调节食和能量平衡至关重要.
早期的营养和荷尔蒙信号可以影响长期的代谢编程.

研究的目的:

为了研究在哺乳期服用叶丁补充剂对大脑的代谢印记效应.
检查与能量平衡和神经营养因子相关的基因表达的性别依赖性改变.

主要方法:

在哺乳期对小鼠幼进行了生理性瘦素补充.
分析累积的食物摄入量,能量效率,瘦身量和下丘脑基因表达.
研究了能量平衡,胰岛素/瘦素信号传导和BDNF通路中的关键基因,包括Bdnf促进物的甲基化分析.

主要成果:

接受丁治疗的小鼠表现出减少食物摄入量,提高能量效率和增加瘦肉量.
Bdnf,Ppargc1a和Fndc5的下丘脑表达受到勒的上调,特别是在女性中.
莱普影响了能量平衡基因和信号通路,取决于性别,AMPK,ACC和STAT3酸化发生了显著变化,女性的Bdnf促进物甲基化发生了改变.

结论:

哺乳期的瘦素补充可以根据性别打印下丘脑基因表达,影响Ppargc1a/Fndc5/Bdnf通路.
这种印记与更苗条的表型有关,在女性中观察到的更明显的积极影响.
早年暴露于素会通过神经营养和信号通路影响长期的代谢编程和能量平衡.

关键词:

这就是为什么BDNF是BDNF.能源平衡能源平衡能源平衡养行为养行为下丘脑的下丘脑是什么意思勒普丁是一种激素.

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