与药物相关的视觉模糊:来自美国食品和药物管理局不良事件报告系统数据库的发现
Shi-Nan Wu1, Xiao-Dong Chen1, Qian-Ting Liu1
1Xiamen University Affiliated Xiamen Eye Center, Fujian Provincial Key Laboratory of Ophthalmology and Visual Science, Fujian Engineering and Research Center of Eye Regenerative Medicine, Eye Institute of Xiamen University, School of Medicine, Xiamen University, Xiamen, Fujian, 361005, China.
European journal of pharmacology
|June 9, 2025
概括
药物诱导的视觉模糊是一个重大问题,有119种药物被确定为潜在的原因. 早期风险评估和个性化药物治疗对于患者的安全和生活质量至关重要.
科学领域:
- 眼科医生 眼科 眼科
- 药物监督 药物监督 药物监督
- 现实世界的证据.
背景情况:
- 视觉模糊是一种常见的眼科症状.
- 药物诱导的不良事件是二次视力模糊的一个重要原因.
- 本研究使用大型现实世界数据库调查与药物相关的视觉模糊.
研究的目的:
- 评估与药物相关的视力模糊的风险.
- 为了确定与视觉模糊相关的特定药物.
- 量化药物诱导的视力模糊的风险,发病率和发病时间.
主要方法:
- 来自美国食品和药物管理局不良事件报告系统 (FAERS) 数据库 (2004年1月至2024年9月) 的不良事件报告分析.
- 应用不成比例分析来识别具有视觉模糊的积极信号的药物.
- 识别药物的分类和风险水平的量化,报告数量和药物诱导的发病时间.
主要成果:
- 119种药物对视觉模糊产生了积极信号,在眼科,内分泌,神经系统,瘤学和抗肌糖药物类别中有显著的关联.
- 利菲特格拉斯特 (Lifitegrast),氧美素 (oxymetazoline) 和奥洛帕塔丁 (olopatadine) 是最常见的视力模糊的前三种药物.
- 抗肌糖药物表现出最短的药物诱导发作时间. 女性和中年到老年人是受影响最严重的人群.
结论:
- 预防与药物相关的视力障碍至关重要.
- 早期风险评估和个性化药物治疗策略可以减轻不良视觉影响.
- 干预措施可以通过减少与药物相关的副作用来提高患者的安全性和提高生活质量.
相关概念视频
01:19Pharmacovigilance
789
Post-marketing surveillance is a critical component of pharmaceutical regulation, often uncovering unanticipated adverse drug reactions (ADRs) once a drug is widely used over an extended period.
This process, termed pharmacovigilance, aims to detect, evaluate, and minimize harmful effects related to medication use. The data collection for pharmacovigilance depends on spontaneous reporting systems, where healthcare professionals or patients voluntarily report suspected ADRs.
In some cases, there...
This process, termed pharmacovigilance, aims to detect, evaluate, and minimize harmful effects related to medication use. The data collection for pharmacovigilance depends on spontaneous reporting systems, where healthcare professionals or patients voluntarily report suspected ADRs.
In some cases, there...
789
01:22Photoreceptors and Visual Pathways
5.9K
At the molecular level, visual signals trigger transformations in photopigment molecules, resulting in changes in the photoreceptor cell's membrane potential. The photon's energy level is denoted by its wavelength, with each specific wavelength of visible light associated with a distinct color. The spectral range of visible light, classified as electromagnetic radiation, spans from 380 to 720 nm. Electromagnetic radiation wavelengths exceeding 720 nm fall under the infrared category,...
5.9K
01:25Drug Regulation
1.3K
Drug regulation encompasses the management of drug usage by evaluating its safety and efficacy through assessments conducted by regulatory authorities. Regrettably, the history of drug regulation is marred by several catastrophic events. One such incident is the Elixir Sulfanilamide tragedy, in which the toxic compound diethyl glycol was included in a sweet-tasting medication, leading to numerous fatalities. This event prompted the enactment of the Food, Drug, and Cosmetic Act in 1938. Under...
1.3K
01:16Focusing of Light in the Eye
2.6K
Light rays enter the eye through the cornea, a transparent dome-shaped tissue that is the eye's outermost layer. The cornea bends or refracts, light rays traveling to the pupil. The shape of the cornea determines how much of the light is bent and whether the image will be focused correctly on the retina at the back of the eye. Once the light has passed through both refraction layers, it converges into a single focal point onto a small area. This is where photoreceptors start transforming...
2.6K