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Updated: Jun 16, 2025

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与染色体结相关的21号染色体放大调节了通过可向的DYRK1A过度表达来转化为爆发期MPN的过程

Charlotte K Brierley1,2,3, Bon Ham Yip4, Giulia Orlando5

  • 1Medical Research Council (MRC) Weatherall Institute of Molecular Medicine (WIMM) and NIHR Biomedical Research Centre, University of Oxford, Oxford, UK. charlotte.brierley@imm.ox.ac.uk.

Nature genetics
|June 9, 2025
PubMed
概括

染色体,一种染色体异常,可以驱动激进的骨髓增殖性瘤 (MPN). 这项研究确定了与不良结果相关的21号染色体放大,并揭示了DYRK1A作为MPN的潜在治疗标.

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