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Updated: Jun 14, 2025

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通过Clostridioides difficile二进制毒素的CDTb成分形成的孔隙是Ca2+依赖的

Dinendra L Abeyawardhane1,2,3, Spiridon E Sevdalis1,2,3, Kaylin A Adipietro1,2,3

  • 1Department of Biochemistry and Molecular Biology, University of Maryland School of Medicine, Baltimore, MD, USA.

Communications biology
|June 9, 2025
PubMed
概括

困难菌的二元毒素 (CDT) 组成部分CDTb与脂质二层结合,并在离子水平下降时形成毛孔. 这种独立于pH的机制涉及与RBD1的解离,引发了CDTb的构造变化.

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