对 perfluoroalkyl 物质和功能进行纵向和横截面分析
概括
这项研究表明,暴露于某些 perfluoroalkyl 物质 (PFAS) 与随着时间的推移功能 (eGFR) 的变化有关. 然而,具体影响因PFAS类型而异,有些表现为积极的,有些表现为反向的关联.
科学领域:
- 环境健康科学 环境健康科学
- 毒理学 毒理学 毒理学
- 腎臟病學 (nephrology) 是一種醫學專業.
背景情况:
- perfluoroalkyl物质 (PFAS) 是广泛使用的化学物质,具有已知的健康影响.
- PFAS对功能的影响,特别是估计的球过率 (eGFR),尚不清楚.
研究的目的:
- 研究PFAS水平与功能 (eGFR) 之间的纵向关系.
- 分析特定的PFAS和eGFR之间的横截面和纵向关联.
主要方法:
- 利用了来自乌普萨拉老年人血管前性调查 (PIVUS) 研究的数据.
- 从997名年龄在70,75和80岁的个体的血中测量了七种主要的PFAS.
- 采用线性回归和混合效应模型,根据各种健康和生活方式因素进行调整.
主要成果:
- 在 perfluoroundecanoic acid (PFUnDA), perfluorononanoic acid (PFNA) 和 perfluorodecanoic acid (PFDA) 和 eGFR之间发现了积极的关联.
- 线性 perfluorooctane 硫酸 (PFOS) 和 perfluorohexanesulfonic 酸 (PFHxS) 显示了类似的积极趋势.
- perfluoroheptanoic 酸 (PFHpA) 和 perfluorooctanesulfonamide (PFOSA) 与eGFR呈现出反向关系.
结论:
- 某些PFAS度的变化与功能变化有关,但该方向因PFAS而异.
- 这些发现得到了纵向和横截面分析的支持.
- 需要对重复测量进行进一步的研究,以充分理解PFAS-功能关系.
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