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感染SARS-CoV-2的甲状腺癌患者的DNA甲基化变化

Jong-Hyuk Ahn¹, Jin Wook Yi^2,3

¹Department of Surgery, Chung-Ang University Hospital, Seoul, Korea.

Updates in surgery

|June 9, 2025

概括

严重急性呼吸道综合征冠状病毒2 (SARS-CoV-2) 感染显著改变了乳头甲状腺癌 (PTC) 组织中的DNA甲基化. 这些表观遗传变化可能会影响瘤抑制基因并影响甲状腺癌的进展.

科学领域:

在瘤学瘤学.
基因组学就是基因组学.
病毒学病毒学

背景情况:

SARS-CoV-2 感染对甲状腺癌的基因组影响尚不清楚.
表观遗传修饰,如DNA甲基化,在癌症的发展和进展中起着至关重要的作用.

研究的目的:

调查最近感染SARS-CoV-2的患者甲状腺癌组织中的DNA甲基化变化.
为了比较COVID-19感染者和大流行前甲状腺癌患者之间的甲基化概况.

主要方法:

使用DNA甲基化EPIC阵列对手术切除的正常甲状腺和乳头甲状腺癌 (PTC) 组织进行分析.
识别差异甲基化探针 (DMP) 和区域 (DMR).
功能性丰富分析,以探索受影响的生物通路.

主要成果:

与对照组相比,COVID-19感染的PTC组织表现出不同的DNA甲基化概况,PTC中的6,848个DMP与正常甲状腺组织中的140个相比.
SARS-CoV-2 感染与 PTC 中瘤抑制基因 (例如 RUNX3,PAOX) 和 Wnt 信号通路基因的高甲基化有关.
在PTC中的关键DMR包括GPR75,CCDC80和ENTPD3,表明细胞粘附,增殖和免疫逃避的潜在变化.

结论:

SARS-CoV-2 感染与乳头甲状腺癌组织中显著的 DNA 甲基化变化有关.
这些表观遗传变化可能会影响甲状腺癌的生物学,进展和攻击性.
需要进一步的研究来验证发现并确定临床相关性.

关键词:

在 COVID-19 疫情中,通过DNA甲基化.表观基因组学是指表观基因组学.新塑性过程新塑性过程这就是SARS-CoV-2病毒.甲状腺癌,乳头癌,乳头癌.

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