慢性型肝炎C患者的口腔表现
Michał Brzdęk1,2, Joanna Gałuszka-Garnuszek3, Krystyna Dobrowolska1
1Collegium Medicum, Jan Kochanowski University, Kielce, Poland.
BMC oral health
|June 9, 2025
概括
型肝炎病毒 (HCV) 感染显著增加了口腔健康问题的风险,包括口腔干燥和疹和平坦等病变. 这些肝外表现的早期检测是管理HCV患者的关键.
科学领域:
- 口腔医学是指口腔医学.
- 肝病学 肝病学是一种肝病学.
- 传染性疾病 传染性疾病
背景情况:
- 型肝炎病毒 (HCV) 感染影响全球5000万,呈现出肝外表现 (EMs).
- 识别EMS对于及时诊断和HCV患者有效的抗病毒治疗至关重要.
- 这项研究研究了HCV感染个体的口腔粘膜症状.
研究的目的:
- 调查慢性C型肝炎病毒 (HCV) 感染患者中影响口腔粘膜的肝外症状的发生率和类型.
- 为了比较HCV感染患者和健康对照者之间的口腔健康状况.
- 确定HCV患者口腔病理的预测因子.
主要方法:
- 一项观察性研究涉及153名慢性HCV患者和健康对照组.
- 数据收集包括人口统计,病史,实验室结果和详细的口腔检查.
- 口腔症状 (口腔干燥,疼痛,灼热) 和病理变化 (角膜炎,乳头炎,平坦) 通过使用标准化尺度进行评估.
主要成果:
- 在HCV患者中,口腔症状的发生率是HCV患者的两倍,口腔干燥最常见.
- 在73.2%的HCV患者中发现了病理性口腔变化,包括候群病,角性炎和平坦,而对照组中只有32%.
- 在HCV组中,口腔卫生状况更差,牙填充物更少. 年龄≥40岁和GT1感染预测口腔病理.
结论:
- 与对照组相比,患有慢性HCV感染的患者表现出明显更高的口腔粘膜病理率.
- кандидоз,角性炎和口腔平坦是HCV患者中最常见的口腔疾病.
- 年龄≥40岁和HCV GT1b基因型是该人口口腔粘膜病变的独立预测因素.
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