肠道微生物群,代谢物和异常性正常压力脑症之间的因果关系:一项两样本的门德尔随机化研究
Wencai Wang1, Menghao Liu1, Zun Wang1
1The Second Affiliated Hospital of Harbin Medical University, Harbin, 150086, People's Republic of China.
BMC neurology
|June 9, 2025
概括
这项研究使用了门德尔的随机化来研究肠道微生物,它们的代谢物和异常正常压力脑症 (INPH) 之间的联系. 发现某些肠道细菌和血清代谢物与INPH风险有因果关系.
科学领域:
- 神经科学是一个神经科学.
- 微生物组研究 微生物组研究
- 代谢学 代谢学 代谢学
背景情况:
- 异常性正常压力脑症 (INPH) 是老年人常见的神经疾病.
- 新出现的证据表明,肠道微生物群,血清代谢物和INPH之间存在联系.
研究的目的:
- 系统地评估肠道微生物群,血清代谢物和INPH之间的潜在因果关系.
- 利用门德尔的随机化 (MR) 方法来评估因果关系.
主要方法:
- 使用了大规模全基因组关联研究的肠道微生物组 (MiBioGen,n=18,340),血清代谢物 (KORA,TwinsUK,n=7,824) 和INPH病例/对照 (767/375,610) 的总结数据.
- 主要分析使用了反变量加权 (IVW) 方法,敏感性分析包括MR-Egger,加权中位数和MR-PRESSO.
- 评估了196种肠道微生物组,486种血清代谢物和INPH之间的因果关系.
主要成果:
- 使用IVW方法确认了9个基因预测的肠道微生物组和INPH之间的因果关系.
- 确定了与INPH相反相关的特定肠道微生物种群 (例如,Clostridiales,Eubacterium eligens群) 和其他 (例如,Melainabacteria,Adlercreutzia) 可能增加INPH风险.
- 发现了25种基因预测血清代谢物和INPH之间的因果关系,敏感性分析支持了结果的稳定性.
结论:
- MR 分析为INPH 中特定肠道微生物种群及其衍生代谢物的因果作用提供了证据.
- 这些发现表明,针对INPH预防和治疗的肠道微生物群和代谢物的潜在治疗策略.
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