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在高活性抗逆转录病毒疗法中甲状腺功能障碍的患病率 - 暴露于感染人类免疫缺陷病毒的人
Asma A Adan1, Redemtor A Ojuang2, Steven G Nyanjom3
1Centre for Microbiology Research, Kenya Medical Research Institute, Nairobi, Kenya.
甲状腺功能障碍影响着超过一半的艾滋病毒感染者 (PLWH),特别是那些接受高活性抗逆转录病毒疗法 (HAART) 的人. 建议进行常规查,以便在这个脆弱人群中早期发现和管理.
科学领域:
- 内分泌学 在内分泌学.
- 传染性疾病 传染性疾病
- 公共卫生 公共卫生
背景情况:
- 甲状腺功能障碍在艾滋病毒感染者中普遍存在,导致疾病和死亡率增加.
- 了解艾滋病患者甲状腺功能障碍的患病率和相关因素对于改善护理至关重要.
研究的目的:
- 确定肯尼亚艾滋病毒感染者 (PLWH) 中甲状腺功能障碍的患病率.
- 在这个人群中确定与甲状腺功能障碍相关的因素,包括HAART使用和HIV病毒载量.
主要方法:
- 收集了临床和社会人口统计数据,包括HIV病毒载量,CD4计数和HAART状态.
- 测量了TSH,FT4和FT3的血清水平.
- 用回归分析和皮尔森相关性来评估关联.
主要成果:
- 超过一半 (51.9%) 的研究PLWH的甲状腺功能障碍.
- 甲状腺功能障碍在HAART治疗患者 (77%) 和非抑制HIV病毒载荷患者 (97%) 中显著较高.
- 艾滋病毒,HAART暴露,结核病共感染和感染的持续时间与甲状腺功能障碍有显著的相关性.
结论:
- 甲状腺功能障碍,主要是亚临床甲状腺功能障碍,在艾滋病毒患者中很常见,特别是那些接受HAART的患者.
- 建议对PLWH进行常规甲状腺查,特别是那些接受HAART并患有病毒漏洞的人.
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