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相关概念视频

lncRNA - Long Non-coding RNAs02:39

lncRNA - Long Non-coding RNAs

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In humans, more than 80% of the genome gets transcribed. However, only around 2% of the genome codes for proteins. The remaining part produces non-coding RNAs which includes ribosomal RNAs, transfer RNAs, telomerase RNAs, and regulatory RNAs, among other types. A large number of regulatory non-coding RNAs have been classified into two groups depending upon their length – small non-coding RNAs, such as microRNA, which are less than 200 nucleotides in length, and long non-coding RNA...
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Alternative RNA Splicing02:18

Alternative RNA Splicing

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Alternative RNA splicing is the regulated splicing of exons and introns to produce different mature mRNAs from a single pre-mRNA. Unlike in constitutive splicing where a single gene produces a single type of mRNA, alternative splicing allows an organism to produce multiple proteins from a single gene and plays an important role in protein diversity.
There are five types of alternative RNA splicing that vary in the ways the pre-mRNA segments are removed or retained in the mature mRNA. The first...
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Types of RNA01:20

Types of RNA

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Three main types of RNA are involved in protein synthesis: messenger RNA (mRNA), transfer RNA (tRNA), and ribosomal RNA (rRNA). These RNAs perform diverse functions and can be broadly classified as protein-coding or non-coding RNA. Non-coding RNAs play important roles in regulating gene expression in response to developmental and environmental changes. Non-coding RNAs in prokaryotes can be manipulated to develop more effective antibacterial drugs for human or animal use.
RNA Performs Diverse...
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piRNA - Piwi-interacting RNAs02:57

piRNA - Piwi-interacting RNAs

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PIWI-interacting RNAs, or piRNAs, are the most abundant short non-coding RNAs. More than 20,000 genes have been found in humans that code for piRNAs while only 2000 genes have been found for miRNAs. piRNAs can act at the transcriptional and post-transcriptional levels and have a vital role in silencing transposable elements present in germ cells. They are also involved in epigenetic silencing and activation. Previously, they were thought to function only in germ cells but new evidence suggests...
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Experimental RNAi02:15

Experimental RNAi

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RNA interference (RNAi) is a cellular mechanism that inhibits gene expression by suppressing its transcription or activating the RNA degradation process. The mechanism was discovered by Andrew Fire and Craig Mello in 1998 in plants. Today, it is observed in almost all eukaryotes, including protozoa, flies, nematodes, insects, parasites, and mammals. This precise cellular mechanism of gene silencing has been developed into a technique that provides an efficient way to identify and determine the...
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Riboswitches01:56

Riboswitches

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Riboswitches are non-coding mRNA domains that regulate the transcription and translation of downstream genes without the help of proteins. Riboswitches bind directly to a metabolite and can form unique stem-loop or hairpin structures in response to the amount of the metabolite present. They have two distinct regions – a metabolite-binding aptamer and an expression platform.
The aptamer has high specificity for a particular metabolite which allows riboswitches to specifically regulate...
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相关实验视频

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RNA Pull-down Procedure to Identify RNA Targets of a Long Non-coding RNA
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植物长非编码RNA:为什么我们不知道更多?

Paulina Kościelniak1, Łukasz Walas2, Agata Konecka3

  • 1Institute of Human Biology and Evolution, Faculty of Biology, Adam Mickiewicz University, Uniwersytetu Poznańskiego 6, 61614, Poznań, Poland.

Biological research
|June 9, 2025
PubMed
概括

由于复杂性和资金,植物基因组数据库落后于人类和动物资源. 了解植物,特别是树木中的长非编码RNA (lncRNAs) 对农业和气候变化弹性至关重要.

关键词:
共同表达是一种共同表达.计算分析 计算分析副转录ome 副转录ome 副转录ome 副转录ome基因组复制是基因组的复制.基因组大小 基因组大小植物 植物 植物聚化是多化的一种.这种物种的分布范围.在ncRNA中,我们可以这是一个小RNARNA.

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科学领域:

  • 基因组学就是基因组学.
  • 分子生物学分子生物学
  • 生物信息学是一种生物信息学.

背景情况:

  • 人类和动物基因组数据库的发展良好,有助于疾病研究和个性化医学.
  • 植物基因组数据库正在快速发展,但由于基因组的复杂性和资金减少,它们的全面性较低.
  • 长非编码RNA (lncRNAs) 对生物体发育至关重要,但它们在植物中的研究面临着重大挑战.

研究的目的:

  • 审查关于植物 lncRNAs 的当前知识状况.
  • 突出植物 lncRNA 研究的障碍,特别是森林树木.
  • 探索ncRNA研究在革命农业和林业方面的潜力.

主要方法:

  • 跨物种基因组数据库开发的比较分析.
  • 植物基因组和lncRNA研究 (复杂性,多重性,表观遗传学) 的挑战审查.
  • 探索用于推进 lncRNA 研究的计算方法.

主要成果:

  • 植物与其他王国之间的基因组数据库全面性存在显著差异.
  • 植物基因组的复杂性,包括多化和表观遗传修饰,使lncRNA研究复杂化.
  • 植物,特别是森林树木中的lncRNAs为农业和林业的气候变化适应提供了潜力.

结论:

  • 迫切需要强大而完整的植物 lncRNA 数据库.
  • 计算分析是克服研究挑战的关键.
  • 森林树木中的lncRNA研究对于应对全球环境挑战和增强农业性至关重要.