硫微生物饮食与所有原因,心血管疾病和癌症死亡率之间的关联:基于人口的队列研究
Lifu Lei1, Yu Sun1, Yushi Chen1
1Department of Clinical Nutrition, The Second Affiliated Hospital of Chongqing Medical University, Chongqing, China.
Molecular nutrition & food research
|June 10, 2025
概括
对硫微生物饮食 (SMD) 的更高坚持与美国成年人全因和癌症死亡率的风险增加有关. 肠道细菌可能会影响与饮食有关的健康结果.
科学领域:
- 营养科学 营养科学
- 微生物组研究 微生物组研究
- 流行病学 流行病学
背景情况:
- 饮食模式显著影响健康结果.
- 硫微生物饮食 (SMD) 在死亡风险中的作用尚未完全理解.
- 人们越来越认识到肠道微生物群对宿主健康的影响.
研究的目的:
- 调查硫微生物饮食 (SMD) 坚持与所有原因,心血管疾病和癌症死亡率之间的关联.
- 探索这些关联中的潜在剂量反应关系和子组差异.
主要方法:
- 利用了前列腺癌,肺癌,结肠直肠癌和卵巢癌查试验中的91,891名成年人的数据.
- 计算了硫微生物饮食 (SMD) 评分,以评估饮食模式的坚持.
- 使用Cox比例危险回归来估计危险比率 (HR) 和95%置信区间 (CI).
主要成果:
- 较高的SMD分数四分位数与所有原因死亡率 (HR: 1.12) 和癌症死亡率 (HR: 1.15) 的风险增加有关.
- 在SMD得分和所有原因和癌症死亡率之间观察到非线性剂量反应关联.
- 在65岁及以上的成年人中发现了SMD得分和全因死亡率之间的显著正相关性.
结论:
- 对硫微生物饮食 (SMD) 的更高坚持与所有原因和癌症死亡率的风险增加有关.
- 肠道硫代谢细菌可能调解饮食和健康结果之间的关系.
- 需要进一步研究肠道微生物群在饮食与疾病相关性中的作用.
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