与艾滋病毒感染者发生痴呆症相关的危险因素
Eunyoung Lee1,2, Young-Gun Lee3, Jihwan Bang1,4
1Division of Infectious Diseases, Seoul Metropolitan Government-Seoul National University Boramae Medical Center, Seoul, Korea.
Journal of Korean medical science
|June 10, 2025
概括
诊断时的年龄较大,社会经济地位较低和艾滋病诊断增加了艾滋病毒感染者的痴呆风险. 早期识别这些因素对于干预至关重要. (33个单词) 的意思.
科学领域:
- 神经科学是一个神经科学.
- 传染性疾病 传染性疾病
- 公共卫生 公共卫生
背景情况:
- 认知能力下降是人类免疫缺陷病毒 (HIV) 感染后的常见并发症.
- 在HIV阳性个体中早期识别痴呆症的风险因素对于及时干预和管理至关重要.
研究的目的:
- 调查HIV诊断时的基线因素,这些因素与发展痴呆症的风险增加有关.
主要方法:
- 一项纵向观察性研究利用了2008-2021年全国索赔数据库.
- 包括40岁以上的艾滋病毒感染者,接受抗逆转录病毒治疗,随访时间超过3年,没有先前的痴呆症诊断.
- 考克斯的比例危险回归模型被用来分析基线特征和事件痴呆之间的关联.
主要成果:
- 在3929名符合条件的艾滋病毒感染患者中 (平均年龄为45岁,男性为90.9%),在平均7.6年的随访期间,114人患上了痴呆症.
- 10年后,累计痴呆症发病率达到4%.
- 确定的重大风险因素包括诊断时的年龄≥50岁 (HR 2.31),低社会经济地位 (HR 3.50) 和诊断时的获得性免疫缺陷综合征 (AIDS) 状态 (HR 2.05).
结论:
- 艾滋病毒诊断时的年龄,社会经济地位和艾滋病诊断时的状态是艾滋病毒感染者痴呆风险的关键决定因素.
- 这些发现凸显了针对高风险个体进行有针对性的监测和支持的需要.
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