韩国PrEP护理中的性风险补偿和保留:HIV PrEP示范研究
Yae Jee Baek1, Yongseop Lee2, Jung Ah Lee2
1Division of Infectious Diseases, Department of Internal Medicine, Soonchunhyang University College of Medicine, Seoul, Korea.
Journal of Korean medical science
|June 10, 2025
概括
暴露前预防 (PrEP) 是安全有效的预防韩国与男性发生性关系的男性 (MSM) 的艾滋病毒. 这项研究发现PrEP用户的性风险行为没有增加.
科学领域:
- 公共卫生 公共卫生
- 传染性疾病 传染性疾病
- 临床药理学 临床药理学
背景情况:
- 使用特诺福维尔二氧化 fumarate和emtricitabine (TDF-FTC) 的暴露前预防 (PrEP) 是一种经过验证的艾滋病毒预防策略.
- 在韩国共和国,特别是与男性发生性关系的男性 (MSM) 中,PrEP的可行性和有效性仍未得到评估.
- 这项研究代表了韩国PrEP的首次演示,提供免费的药物,实验室测试和诊所访问.
研究的目的:
- 评估韩国HIV阴性MSM每日口服PrEP (TDF-FTC) 的可行性和安全性.
- 评估这一群体内的艾滋病毒和性传播感染 (STI) 发病率.
- 分析与PrEP使用相关的坚持,不良事件和潜在的风险补偿行为.
主要方法:
- 艾滋病毒阴性MSM每天接受TDF-FTC,并定期参加门诊诊所的访问.
- 评估包括关于不良反应,坚持和性行为的问卷.
- 收集了残留药片数量,血和尿液样本,以测量诺福维二酸盐 (TFV) 度.
主要成果:
- 总共有100名参与者接受了平均392天的随访,保养率为77%.
- 艾滋病毒发病率为每100人/年0.98;性传播疾病发病率为每100人/年13.67. 没有观察到任何严重的不良事件.
- 在28周达到55.3%,在52周达到41.7%,达到足够的TFV度 (>40 ng/mL). 阳性STI结果与更高的TFV水平相关 (aOR,3.67;P=0.034).
结论:
- 每日口服PrEP (TDF-FTC) 在韩国MSM中证明了安全性和有效性.
- 使用PrEP与增加性风险行为无关,这表明没有显著的风险补偿.
- 这项研究提供了对东亚PrEP使用者风险补偿的首次分析.
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