在抛物线飞行中的重力挑战期间,外围皮肤冷却 - - CoolFly实验的实验协议,实施和案例研究
Tomas L Bothe1, Viktor Heinz1,2, Niklas Pilz3
1Charité - Universitätsmedizin Berlin, Institute of Physiology, Center for Space Medicine and Extreme Environments, Berlin, Germany.
Frontiers in physiology
|June 10, 2025
概括
周围冷却 (PC) 是一种可行的方法,可以在太空飞行中的模拟重力变化期间保持心血管稳定. 这种技术降低了心率和血压波动,表明其作为太空旅行对策的潜力.
科学领域:
- 太空医学 太空医学
- 心血管生理学心血管生理学
- 航空航天工程是航空航天工程.
背景情况:
- 人类太空飞行需要在变化的重力中保持心血管稳定.
- 宇航员因动态加速和长时间的重力变化而面临健康风险.
- 抛物线飞行作为研究引力诱导的心血管不稳定的模型.
研究的目的:
- 评估作为对策的外围冷却 (PC) 的可行性和有效性.
- 分析PC在模拟引力变化期间对心血管反应的影响.
- 为PC在太空飞行场景中的应用提供概念验证.
主要方法:
- 采用了交叉试验设计.
- 持续,非侵入性监测血压,心率,氧化,血流和温度.
- 使用抛物线飞行模拟引力变化.
主要成果:
- 外围冷却使心率降低了10.0%,并稳定了心率的变化.
- 对重力变化的血压反应显著减弱 (-9/+8 mmHg与PC相比 -20/+39 mmHg没有).
- 皮肤和大脑核心温度的最小变化以及微 perfusion 改变的减少在 PC 观察到.
结论:
- 在抛物线飞行期间,外围冷却是可行的.
- PC显示有潜力减弱心血管对引力变化的反应.
- 需要进一步的研究来验证PC作为非侵入性太空飞行对策.
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