芯片上的瘤微血管揭示了癌症细胞集群血管内流的机制
Yukinori Ikeda1,2, Makoto Kondo1,2, Jun-Ichi Suehiro3
1Institute of Industrial Science, The University of Tokyo, 4-6-1 Komaba, Meguro-ku, Tokyo 153-8505, Japan.
iScience
|June 10, 2025
概括
循环瘤细胞 (CTC) 集群驱动转移. 一个新的3D模型揭示了这些癌细胞群是如何入侵血管的,为预防瘤扩散提供了新的治疗点.
科学领域:
- 在瘤学瘤学.
- 细胞生物学 细胞生物学
- 生物医学工程 生物医学工程
背景情况:
- 循环瘤细胞 (CTC) 集群与转移和高度瘤的不良预后有关.
- 从初级瘤释放到循环中的CTC集群释放机制尚未完全理解.
研究的目的:
- 为了研究瘤细胞集群输血和从原发性瘤释放的机制.
- 开发一种用于可视化瘤细胞集群入侵的3D体外模型.
主要方法:
- 使用瘤有机体和微容器开发一个3D体外培养系统.
- 可视化瘤血管内扩散,集体迁移和血管选择.
- 分析瘤微环境中的分子因素,包括TGF-β和活性素.
主要成果:
- 可视化了一种新的瘤输血机制,涉及集体迁移和血管选择.
- 内皮细胞中TGF-β和活性因的升高促进了瘤细胞的血管内扩散.
- 微容器中的内皮转移到介质细胞转换 (EndoMT) 与CTC集群释放有关.
结论:
- 这项研究阐明了一种以前未报告的CTC集群释放机制.
- 开发的3D体外系统为研究瘤转移提供了一个平台.
- 向CTC集群释放是一种潜在的治疗策略,可以对抗癌症转移.
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