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肠道微生物群的饮食指数与高尿血之间的关系:使用NHANES数据进行的横截面研究

Xin Cai¹, Shaoqin Zhang¹, Tianzuo Lan¹

¹The First People's Hospital of Guiyang, Guiyang, China.

Frontiers in nutrition

|June 10, 2025

概括

较高的肠道微生物群 (DI-GM) 饮食指数得分与较低的高尿路血症 (HUA) 风险有关. 这表明饮食通过肠道微生物群相互作用来控制尿酸水平.

科学领域:

代谢健康代谢健康
肠道微生物组研究研究
营养流行病学营养流行病学

背景情况:

超尿血症 (HUA) 是一种普遍的代谢障碍,其饮食和肠道微生物群的影响尚未完全理解.
饮食模式和肠道微生物群组成越来越被认为是代谢调节的关键因素.

研究的目的:

调查肠道微生物群的饮食指数 (DI-GM) 与高尿素血 (HUA) 的患病率之间的关联.
为了分析这种关系,使用一个庞大的,具有全国代表性的成年人群.

主要方法:

利用了国家健康和营养检查调查 (NHANES) 2007-2020年期间的数据.
包括25,899名成年人,根据饮食回忆计算DI-GM,并通过实验室结果诊断HUA.
使用多变量后勤回归来评估DI-GM和HUA关系,控制混因素.

主要成果:

较高的DI-GM得分与降低HUA的可能性显著相关 (OR=0.968,p=0.005).
与得分为0-3 (OR=0.897,p=0.016) 的人相比,DI-GM得分为6或更高的人患HUA的风险要低得多.

结论:

较高的DI-GM得分表明与高尿路血症风险的反向关系.
针对肠道微生物群的饮食干预措施可能提供一种管理HUA的策略.

关键词:

尼汉斯 (NHANES) 是一个名人.饮食指数饮食指数饮食指数肠道微生物群的饮食指数超血症是什么意思营养流行病学营养流行病学

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