在二次心血管预防中测量阿司匹林的坚持和持续性的方法和有效性指标:系统性审查
Rauf Nouni-García1,2,3,4, Elisabeth Ramirez-Familia5, Adriana López-Pineda3,4,5
1Pathology and Surgery Department, Medical School, University Miguel Hernández de Elche, Alicante, Spain.
患者坚持服用阿司匹林 (乙盐酸,ASA) 以预防心血管疾病至关重要,但往往不理想. 这次审查发现当前的测量方法缺乏具体的验证,强调需要改进的工具来有效地跟踪ASA使用.
科学领域:
- 心脏病学 心脏病学
- 药理学 药理学 是一个学科.
- 医疗保健服务研究 医疗服务研究
背景情况:
- 阿司匹林 (乙撒利酸,ASA) 是二次心血管预防 (SCP) 的基石.
- 低于最佳的患者对ASA的坚持和持久性限制了其在SCP中的临床有效性.
- 了解ASA坚持和持久性的当前测量方法对于改善患者的治疗结果至关重要.
研究的目的:
- 系统地审查和确定用于评估SCP中ASA的坚持和持久性的方法.
- 评估这些测量方法在SCP中ASA的有效性指标.
主要方法:
- 在EMBASE,MEDLINE和Scopus的系统文献搜索到2023年10月30日.
- 包括40项研究报告了在接受SCP的成年人中对ASA坚持或持久度的测量.
- 关于研究特征,测量方法 (直接/间接) 和有效性指标的数据提取;用于验证研究的偏差风险评估.
主要成果:
- 间接方法,主要是自我报告问卷和药房发行记录,主导了ASA遵守评估.
- 像血小板功能测试这样的直接方法对于坚持是不太常见的;分发记录最常用于持久性.
- 特别针对ASA坚持或持久性的间接方法报告的验证显著缺乏.
结论:
- 目前用于测量二次心血管预防中的阿司匹林坚持和持久性的方法缺乏具体的验证.
- 有必要开发标准化,验证的工具,将直接和间接措施结合起来.
- 解决性别特定的坚持障碍对于改善SCP中阿司匹林使用至关重要.
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