一个诊断预测模型用于心血管疾病 (CVD) 在患有牛皮的患者
Xiao-Yang Guo1, Guo-Hua Xue1, Yue-Min Zou1
1Beijing University of Chinese Medicine, Beijing, China.
Frontiers in cardiovascular medicine
|June 10, 2025
概括
牛皮患者患心血管疾病 (CVD) 的风险更高. 这项研究开发了一种使用年龄,高血压,糖尿病,脂质失调和禁食血糖来预测牛皮患者心血管疾病风险的诺米克图,有助于早期诊断和干预.
科学领域:
- 皮肤病学 皮肤病学
- 心脏病学 心脏病学
- 医疗信息学 医疗信息学
背景情况:
- 牛皮与心血管疾病 (CVD) 的风险显著增加有关,这是受影响个体死亡的主要原因.
- 早期发现和治疗心血管疾病对于减缓牛皮患者疾病进展至关重要.
研究的目的:
- 开发和验证用于诊断牛皮患者心血管疾病 (CVD) 的预测模型.
- 创建一个实用工具,帮助医生识别心血管疾病的高风险牛皮患者.
主要方法:
- 对2685名牛皮患者的病历进行了回顾性审查.
- 使用单变量逻辑回归和LASSO进行变量选择,然后使用多变量逻辑回归进行名ogram构造.
- 通过引导重新抽样和NHANES数据进行内部和外部验证.
主要成果:
- 开发了一种包含年龄,高血压,糖尿病,脂质失调和禁食血糖 (FBG) 的名图.
- 该模型表现出有利的歧视,内部AUC为0.9355 (培训) 和0.9118 (验证),外部AUC为0.8293.
- 该模型与以前的诊断模型相比显示出更高的性能,由阳性NRI和IDI表示.
结论:
- 开发的名图是个具有成本效益和实用的工具,用于识别患有心血管疾病高风险的牛皮患者.
- 早期识别有助于及时诊断和干预,可能改善患者的治疗结果.
- 该模型的强有力的验证证实了其在治疗牛皮的并发性心血管疾病中的临床实用性.
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