相关实验视频

Updated: Jun 12, 2025

A Method for Targeted 16S Sequencing of Human Milk Samples

A Method for Targeted 16S Sequencing of Human Milk Samples

Published on: March 23, 2018

哺乳期间母乳寡糖分泌的动态及其抗菌作用:系统性审查

Mohammed Al-Beltagi^1,2

¹Department of Paediatrics, Faculty of Medicine, Tanta University, Tanta 31511, Alghrabia, Egypt.

World journal of clinical pediatrics

|June 10, 2025

概括

人类母乳寡糖 (HMO) 在哺乳期动态变化,并具有抗菌性质. 无论是天然的还是合成的HMO都对婴儿健康和作为抗生素辅助剂有希望.

科学领域:

生物化学生化学
微生物学微生物学
免疫学免疫学免疫学

背景情况:

人类母乳寡糖化物 (HMO) 是母乳中重要的生物活性成分.
它们影响婴儿的肠道微生物群,免疫力和感染防御.
根据母亲的因素,HMO分泌有所不同,它们的抗菌作用需要更深入的理解.

研究的目的:

审查哺乳期HMO分泌动态.
评估HMO对各种病原体的抗微生物活性.
综合有关HMO在婴儿健康中的作用的证据.

主要方法:

在主要数据库 (PubMed,Scopus等) 的系统文献搜索. ) 的情况.
包括在人体,动物和体外模型中对天然和合成HMO的研究.
提取和分析有关HMO成分,分泌模式和抗菌机制的数据.

主要成果:

HMO分泌模式各不相同,特定类型在不同的哺乳期达到峰值.
人类基因组抑制了病原体的粘附,破坏了生物膜,并损害了酶活性.
合成HMO模仿天然的,对大肠杆菌和P. aeruginosa等病原体表现出有效性.
人类抗菌组织 (HMO) 增强抗生素对抗耐药菌株的有效性.

结论:

对婴儿抗菌防御各种病原体而言,HMO至关重要.
天然和合成的HMO在婴儿营养和作为抗生素辅助剂都具有治疗潜力.
需要进一步的临床研究来证实HMO对母亲和新生儿健康的益处.

关键词:

抗微生物活性的抗菌活性.哺乳期哺乳期哺乳期人类牛奶中的寡糖类.人类牛奶寡糖分泌的动态人类牛奶寡糖分泌的动态婴儿健康婴儿健康病原体粘附抑制抑制病原体粘附抑制合成的人类牛奶寡糖化物.

更多相关视频

Individualized Reconstitution of Human Milk Microbiota: A Feasible Approach in Real-World Settings

Individualized Reconstitution of Human Milk Microbiota: A Feasible Approach in Real-World Settings

Published on: February 7, 2025

Analysis of Fucosylated Human Milk Trisaccharides in Biotechnological Context Using Genetically Encoded Biosensors

Analysis of Fucosylated Human Milk Trisaccharides in Biotechnological Context Using Genetically Encoded Biosensors

Published on: April 13, 2019

相关概念视频

Surface Membrane Barriers

Surface Membrane Barriers

The skin and mucous membranes serve as the primary line of defense against pathogens by providing both physical and chemical protection. These barriers are essential in preventing the entry and establishment of microbes, thereby maintaining the integrity of the host.
The outer layer of the skin, the epidermis, is a robust barrier comprising layers of closely packed keratinized cells. This dense arrangement prevents microbes from penetrating the body. The periodic shedding of epidermal cells...

Transcytosis of IgG

Transcytosis of IgG

Transcytosis is the process in which molecules are internalized by endocytosis, transported across the cell, and released through exocytosis from the opposite end of the cell. Molecules such as insulin, immunoglobulins, and certain nutrients are transferred through the recycling endosomes by recycling and transcytosis.
IgG molecules from a mother undergo transcytosis starting around 13 weeks of gestation. The amount of IgG transferred and entering the fetal blood circulation increases with...