不同颗粒细胞殖民地刺激因子方案对欧体胚胎移植患者在复发性植入失败中的影响
Ozge Karaosmanoglu1, Aysen Yuceturk1, Ilke Ozer Aslan1
1Assisted Reproductive Technologies Unit, Acibadem Maslak Hospital, Istanbul, Türkiye.
Frontiers in medicine
|June 10, 2025
概括
结合子宫内和皮下颗粒细胞殖民地刺激因子 (G-CSF) 的治疗,改善了复发性植入失败的女性进行胚胎移植的怀孕和活产率.
科学领域:
- 生殖内分泌学 生殖内分泌学
- 不孕症研究 不孕症研究
- 胚胎移植协议 胚胎移植协议
背景情况:
- 复发性植入失败 (RIF) 在辅助生殖技术中构成了重大挑战.
- 确定有效的干预措施以改善RIF患者的妊娠结果至关重要.
研究的目的:
- 为了评估不同细粒细胞殖民地刺激因子 (G-CSF) 方案在接受euploid胚胎移植的RIF患者的疗效.
- 为了比较G-CSF治疗组和对照组之间的怀孕和活产率.
主要方法:
- 一项回顾性队列研究,包括293名RIF女性.
- 三组:子宫内G-CSF,子宫内和皮下联合G-CSF,以及对照组.
- 标准的激素制剂与雌激素和孕激素.
主要成果:
- 结合的G-CSF组显示出明显更高的怀孕率 (65.9%) 与对照组 (50.5%) 相比.
- 在G-CSF组合组 (55.7%) 与对照组 (40.6%) 的活产率显著更高.
- 只有宫内G-CSF组和对照组之间没有观察到对初级结果的统计学上显著的差异.
结论:
- 在子宫内注射中添加皮下G-CSF可能会提高RIF患者的阳性妊娠测试结果和活产率.
- 联合G-CSF治疗似乎是一个有前途的策略,用于改善具有挑战性的不孕症病例的结果.
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