增加饮食中的酸含量可能会增加冠状动脉疾病严重程度的风险:横截面研究的发现
Zeinab Ghorbani1,2, Fatemeh Dashti1,3, Zahra Saeedirad4
1Cardiovascular Diseases Research Center, Department of Cardiology, Heshmat Hospital, School of Medicine, Guilan University of Medical Sciences, Rasht, Iran.
概括
通过潜在脏酸负荷 (PRAL) 和内源性净酸产量 (NEAP) 测量的较高的食酸负荷与严重冠状动脉疾病 (CAD) 的风险增加有关. 这表明酸性饮食可能会使动脉样硬化恶化.
科学领域:
- 营养科学 营养科学
- 心血管健康 心血管健康
- 代谢障碍 代谢障碍 代谢障碍
背景情况:
- 慢性低度代谢酸症与慢性疾病的发展有关.
- 饮食中的酸含量可能会影响代谢过程和疾病风险.
研究的目的:
- 调查潜在的酸负载 (PRAL) 和内源性净酸产量 (NEAP) 与严重冠状动脉疾病 (CAD) 风险之间的关联.
- 为了探索潜在的非线性关系使用限制立方线 (RCS) 回归.
主要方法:
- 从营养赫什马特注册 (NUTHER) 的895名参与者的横截面研究.
- 通过食物频率问卷收集的饮食数据来计算PRAL和NEAP.
- 逻辑回归和RCS回归用于分析严重的CAD风险 (根西尼分数≥60).
主要成果:
- 增加PRAL和NEAP与调整混因素后更高的严重CAD几率有关.
- 能量调整后PRAL的第4个四分位数显示严重CAD的概率高1.62倍 (OR:1.62;95%CI:1.05,2.51).
- NEAP的第4个四分位数显示严重CAD的概率高1.67倍 (OR:1.67;95%CI:1.07,2.61).
- RCS分析显示,PRAL与严重CAD风险之间存在线性关联,NEAP与严重CAD风险之间存在非线性关联.
结论:
- 饮食中较高的酸含量显著与严重冠状动脉疾病的风险增加有关.
- 酸性饮食可能会促进动脉样硬化的进展.
- 需要进一步的前性研究来证实这些发现.
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