老年人骨肌量与认知障碍之间的关系:基于CLHLS的纵向研究
Shani Feng1, Kaixuan Xie2, Yu Zhang2
1The Second People's Hospital of Yuhuan, Yuhuan, China.
Frontiers in public health
|June 10, 2025
概括
保持更高的骨肌肉质量与老年人认知障碍风险降低有关. 这种关系是非线性的,并因性别而异,突出显示了肌肉质量对大脑健康的重要性.
科学领域:
- 老年学是一门学科.
- 神经科学是一个神经科学.
- 公共卫生 公共卫生
背景情况:
- 认知障碍在老年人群中越来越令人担忧.
- 骨肌肉质量自然会随着年龄的增长而下降,这种情况被称为sarcopenia.
- 老年人肌肉健康和认知功能之间的相互作用需要进一步研究.
研究的目的:
- 调查骨肌肉质量与老年人认知障碍风险之间的剂量反应关系.
- 探索该协会中潜在的性别差异.
主要方法:
- 来自中国老年成年人健康影响因素纵向调查项目的纵向调查数据分析 (2008-2018).
- 包括2,199名老年人 (年龄在61-108岁之间) 在10年内收集的数据中.
- 应用考克斯回归和限制立方分线 (RCS) 模型来评估关联及其非线性趋势.
主要成果:
- 在骨肌肉质量和认知障碍之间观察到显著的非线性关联 (P <0.05 趋势和非线性).
- 较高的骨肌肉质量证明了对认知障碍的保护作用.
- 尾骨肌指数 (ASMI) 的特定值被确定为风险因素:男性<7.2 kg/m2,女性<5.4 kg/m2.
结论:
- 骨肌肉质量是与老年人认知障碍相关的重要因素.
- 保持足够的骨肌肉质量,以性别特定的目标,可能是预防认知衰退的可行策略.
- 旨在改善或维持肌肉质量的早期干预措施可以支持老年人群的认知健康.
相关概念视频
01:30Cognitive Development During Adulthood
65
Cognitive development continues throughout adulthood, undergoing significant shifts across early, middle, and late stages. Individual transition occurs from adolescent idealism to pragmatic and adaptable thinking in early adulthood. During this period, individuals learn to integrate personal beliefs with the recognition that other perspectives are equally valid. Exposure to the complexities of modern society, diverse experiences, and higher education contribute to this adaptive thought process,...
65
01:26Cross-bridge Cycle
117.0K
As muscle contracts, the overlap between the thin and thick filaments increases, decreasing the length of the sarcomere—the contractile unit of the muscle—using energy in the form of ATP. At the molecular level, this is a cyclic, multistep process that involves binding and hydrolysis of ATP, and movement of actin by myosin.
117.0K
01:28Disorders of the Skeletal Muscle
903
The clinical conditions affecting the skeletal muscle tissue are broadly categorized as musculoskeletal and neuromuscular disorders.
Musculoskeletal disorders
Musculoskeletal disorders involve injuries and conditions affecting the skeletal muscles and associated connective tissues. These disorders can arise from acute biomechanical stresses or chronic overuse and can occur across different age groups. Common injuries include sprains, fractures, and muscular strains, often resulting from...
Musculoskeletal disorders
Musculoskeletal disorders involve injuries and conditions affecting the skeletal muscles and associated connective tissues. These disorders can arise from acute biomechanical stresses or chronic overuse and can occur across different age groups. Common injuries include sprains, fractures, and muscular strains, often resulting from...
903
01:29Bone Disorders
3.4K
Aging and its effect on bone remodeling is the most common cause of bone disorders. In young and healthy people, bone deposition and resorption happen at an equal rate to maintain optimal bone health.
Bone deposition is also affected by the levels of sex hormones like estrogen and testosterone that promote osteoblast activity and bone matrix synthesis. When the level of these hormones decreases due to aging, it causes a reduction in bone deposition. As a result, bone resorption by osteoclasts...
Bone deposition is also affected by the levels of sex hormones like estrogen and testosterone that promote osteoblast activity and bone matrix synthesis. When the level of these hormones decreases due to aging, it causes a reduction in bone deposition. As a result, bone resorption by osteoclasts...
3.4K
01:27Language and Cognition
335
Language serves as a bridge between ideas and communication, influencing how individuals perceive and interact with the world. Psychologists have long debated whether language shapes thought or vice versa. This discussion gained grip with Edward Sapir and Benjamin Lee Whorf in the 1940s, who proposed that language determines thought, a concept known as linguistic determinism. They suggested that the vocabulary and structure of a language influence how its speakers think and perceive reality.
335