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骨关节感染中的BioFire:用于早期和准确诊断的快速综合征测试 - 一个叙述性审查

Vibhu Krishnan Viswanathan¹, Vijay Kumar Jain², Karthikeyan P Iyengar³

¹Department of Orthopedics, IORAS, Madurai, India.

Journal of clinical orthopaedics and trauma

|June 10, 2025

概括

生物Fire®关节炎面板 (BFAP) 可快速识别常见的骨关节感染病原体和耐药性标志物. 然而,它的准确性在非面板生物体下降,影响了对某些感染的诊断.

科学领域:

微生物学微生物学
分子诊断学分子诊断
传染性疾病传染性疾病

背景情况:

多种耐药性病原体带来越来越大的风险,需要快速识别方法.
像BioFire®关节炎面板 (BFAP) 这样的多重分子技术对于评估骨关节感染 (OI) 是至关重要的.

研究的目的:

综合审查BioFire®关节炎小组在诊断骨关节感染中的当前状态和临床实用性.

主要方法:

在5个数据库中,在2024年6月进行了文献搜索.
包括评估OI中BFAP的临床研究 (前性和后性);实验研究,社论和评论被排除在外.
对于十个选定的手稿,使用了叙事综合方法.

主要成果:

该BFAP采用自动化盒子方法,在约1小时内识别出31种微生物和8种耐药性标记物.
该面板对面板上的病原体具有很高的诊断精度 (90.9%的灵敏度,98.5%的特异性).
对非面板病原体 (例如, * Staphylococcus epidermidis * * Cutibacterium acnes *) 的敏感性显著降至 56%,导致潜在的虚假阴性结果.

结论:

BFAP提供快速的结果,对目标病原体具有高灵敏度/特异性,并检测抗菌素耐药性,有利于原生败血性关节炎和儿科OI.
排除特定生物体限制了BFAP在诊断周围假肢关节感染 (PJI) 和慢性OI的敏感性和准确性.

关键词:

抗菌剂是一种抗菌剂.抗微生物耐药性抗微生物耐药性在BioFire®的面板上.骨和关节感染骨和关节感染诊断测试诊断测试诊断测试诊断测试诊断测试假肢关节感染假肢关节感染

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