稳定性,生物可用性和细胞抗氧化活性与循环葡萄糖复合的皮佩林
Solji Cho1,2, Yunkyoung Jung3, Shin-Joung Rho3
1Department of Biosystems Engineering, Seoul National University, Seoul, 08826 Republic of Korea.
Food science and biotechnology
|June 10, 2025
概括
复杂化piperine与循环葡萄糖,特别是循环胺基 (CA),增强其溶解性,稳定性和生物可用性. 这种包含综合体 (IC) 策略改善了管道.
科学领域:
- 药理学和药物输送 药理学和药物输送
- 自然产品化学 自然产品化学
- 材料科学 材料科学 材料科学
背景情况:
- 黑胡中的活性化合物皮佩林具有较低的溶解性和生物可用性.
- 改善皮佩林的物理化学特性对于其工业应用至关重要.
研究的目的:
- 为了研究 piperine 与周期性葡萄糖 (cycloamylose,α-cyclodextrin,2-hydroxypropyl-β-cyclodextrin) 的复合.
- 评估复杂化对皮佩林可溶性,稳定性,生物可用性和细胞抗氧化活性 (CAA) 的影响.
主要方法:
- 在 piperine 和各种循环葡萄糖之间形成包含综合体 (IC).
- 阶段可溶性研究,以评估可溶性增强.
- 在紫外线,热量和酸性条件下进行稳定性测试.
- 在体外消化和Caco-2细胞单层透性测试.
- 细胞抗氧化剂活性测定.
主要成果:
- 纳入复杂化显著改善了piperine的相位溶解性和稳定性.
- 在体外消化后,ICs增强了piperine的保留,并降低了其排泄率.
- 循环氨基含复合物 (CAIC) 显示了细胞吸收和CAA.最显著的改善.
结论:
- 循环葡萄糖复合,特别是循环胺,是一种有效的策略,可以提高皮佩林的溶解性和生物可用性.
- 这种方法提供了一个实际的解决方案,用于将piperine纳入各种工业应用中.
- 通过循环胺含复合物观察到增强的细胞吸收和抗氧化活性.
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