抗氧化能力和先进的糖化终产品之间的相关性 抑制来自Sargassum fusiforme的酶处理的多糖体
Young Sung Jung1,2, Chi Heung Cho1, Mingyeong Kim1,3
1Food Functionality Research Division, Korea Food Research Institute, Wanju-Gun, 55365 Republic of Korea.
Food science and biotechnology
|June 10, 2025
概括
来自Sargassum fusiforme (EPS) 的酶处理的海洋多糖体显示出改善的抗氧化和抗糖化特性. 较低的分子量提高了它们在控制氧化应激和相关疾病方面的有效性.
科学领域:
- 海洋生物技术 海洋生物技术
- 食品科学 食品科学 食品科学
- 生物化学 生物化学
背景情况:
- 海洋多糖类具有抗氧化特性,但由于高分子量,其生物利用性较低.
- 在人体肠道中,酶性消化是有限的,阻碍了这些化合物的功能有效性.
- 氧化应激和高级糖化最终产品 (AGEs) 与各种慢性疾病有关.
研究的目的:
- 为了研究来自Sargassum fusiforme (EPS) 的酶处理多糖的抗氧化和抗糖化潜力.
- 为了确定分子量减少对这些海洋多糖的生物活性的影响.
- 探索EPS在管理氧化应激和AGE相关条件中的应用.
主要方法:
- Sargassum fusiforme 聚糖被用包括α-氨酶和细胞酶在内的酶处理.
- 用酶处理的多糖体 (EPS) 分析了分子量分布和残留金属离子含量.
- 评估了抗氧化能力和先进糖化最终产品 (AGE) 抑制.
- 相关性和主要成分分析被用来将分子量与生物活性联系起来.
主要成果:
- 酶治疗显著降低了Sargassum状多糖的分子量.
- 与未经处理的多糖相比,EPS显示了增强的抗氧化能力.
- EPS显著抑制了先进的糖化最终产品 (AGE) 的形成.
- 在降低分子量和增加抗氧化剂和抗糖化活性之间发现了积极的相关性.
结论:
- 来自Sargassum fusiforme的受酶处理的多糖化物 (EPS) 提供了更好的生物可用性和生物活性.
- 作为抗氧化应激和AGE相关疾病的天然治疗剂,EPS具有显著的潜力.
- 这些发现支持在功能性食品和营养保健品中使用EPS以获得健康益处.
更多相关视频
相关概念视频
01:24Oligosaccharide Assembly
Protein glycosylation starts in the ER lumen and continues in the Golgi apparatus. Glycosyltransferases catalyze the addition of sugar molecules or glycosylation of proteins. Usually, these enzymes add sugars to the hydroxyl groups of selected serine or threonine residues to form O-linked glycans or the amino groups of asparagine residues to form N-linked glycans. Different positions on the same polypeptide chain can contain differently linked glycans.
Multiple sugar molecules that may or may...
Multiple sugar molecules that may or may...
01:10Sugars as Energy Storage Molecules
Sugar (a simple carbohydrate) metabolism (chemical reactions) is a classic example of the many cellular processes that use and produce energy. Living things consume sugar as a major energy source because sugar molecules have considerable energy stored within their bonds. Consumed carbohydrates have their origins in photosynthesizing organisms like plants. During photosynthesis, plants use the energy of sunlight to convert carbon dioxide gas into sugar molecules, like glucose. Because this...
01:10Sugars as Energy Storage Molecules
Sugar (a simple carbohydrate) metabolism (chemical reactions) is a classic example of the many cellular processes that use and produce energy. Living things consume sugar as a major energy source because sugar molecules have considerable energy stored within their bonds. Consumed carbohydrates have their origins in photosynthesizing organisms like plants. During photosynthesis, plants use the energy of sunlight to convert carbon dioxide gas into sugar molecules, like glucose. Because this...
01:19Oral Hypoglycemic Agents: α-Glucosidase Inhibitors
α-glucosidase inhibitors, including acarbose (Precose), miglitol (Glyset), and voglibose (Voglib) (primarily available in Asia), are drugs that control blood sugar levels by delaying the digestion of starch and disaccharides. They achieve this by inhibiting α-glucosidase enzymes in the intestine, which slow the absorption of carbohydrates in the intestine, which in turn leads to a prolonged release of the glucoregulatory hormone GLP-1 from intestinal L-cells.
Acarbose and miglitol are typically...
Acarbose and miglitol are typically...
01:27Production of Alcohol
Continuous fermentation is a key strategy in industrial ethanol production, particularly when efficiency, scalability, and high yields are essential. This approach allows for uninterrupted operation and optimized resource utilization. The primary feedstock, corn starch, undergoes enzymatic hydrolysis facilitated by α-amylase and glucoamylase. These enzymes break down the starch into fermentable sugars such as glucose, which are readily assimilated by fermentative microorganisms.Fermentation...
01:25Production of Organic Acids
Lactic acid, an important organic acid extensively applied in food, pharmaceutical, and biodegradable polymer industries, is primarily produced via microbial fermentation. This method is favored over chemical synthesis due to its environmental sustainability and capacity for enantiomerically pure product formation. Among various microbial processes, the fermentation of starch-based substrates stands out due to the abundance and renewability of raw materials like corn and potatoes.Hydrolysis of...