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对与物质使用障碍相关的大脑体积变化的寿命调查

Runye Shi¹, Shitong Xiang^2,3, Dag Alnæs^4,5

¹School of Data Science, Fudan University, Shanghai, China.

medRxiv : the preprint server for health sciences

|June 10, 2025

概括

药物使用障碍 (SUD) 影响整个寿命的大脑结构. 关键的发育阶段显示出明显的体积变化,为神经生物学机制和治疗时间提供了洞察力.

科学领域:

神经科学是一个神经科学.
公共卫生公共卫生
遗传学遗传学是一个

背景情况:

药物使用障碍 (SUD) 是一个主要的公共卫生问题,具有重大的社会成本.
虽然SUD中的结构性大脑变化已知,但潜在的神经机制和寿命体积变化尚未得到充分探索.

研究的目的:

在整个生命周期中调查SUD的神经生物学机制和基因组基础.
为了比较SUD个体与健康对照个体的全脑体积轨迹.

主要方法:

来自四大人口队伍的协调的神经成像,行为和基因组数据.
在SUD和健康对照人群之间,比较了整个大脑体积轨迹的寿命.

主要成果:

确定了SUD发展的三个关键生命阶段:青春期-早期成年期 (神经发育失衡),早期-中期成年期 (强迫性相关的变化) 和中后期成年期 (神经毒性).
通过纵向和独立的横截面分析验证了结果.

结论:

证明了与SUD相关的全脑体积变化.
揭示了潜在的神经行为机制和SUD预防和治疗的关键时间窗口.

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