亚洲人群中的脂蛋白和心血管风险:综合性审查
1Division of Endocrinology and Metabolism, Department of Internal Medicine, Korea University College of Medicine, Seoul, Korea.
Journal of lipid and atherosclerosis
|June 10, 2025
概括
脂蛋白 (Lp) 是心血管疾病的关键驱动因素. 本综述考察了亚洲人群中的Lp(a),指出了较低水平但持续的风险,并探索了新的治疗方法.
科学领域:
- 心血管医学 心血管医学
- 遗传学 是一个遗传学.
- 流行病学 流行病学
背景情况:
- 脂蛋白 (Lp) 是一种由基因决定的粒子,与动脉样硬化心血管疾病 (ASCVD),缺血性中风和动脉狭窄症有因果关系.
- 由于其阿波利波蛋白[阿波利波蛋白]组成部分,Lp (a) 具有独特的异质性质,与低密度脂蛋白不同.
- 在Lp(a) 水平存在种族差异,东亚人通常由于特定的LPA基因变异和apo(a) 异型而显示较低的中位数度.
研究的目的:
- 审查亚洲人群中Lp (a) 的流行病学,遗传因素,临床意义和治疗策略.
- 突出需要特定于种族的Lp (a) 门和对这一人口群体的进一步研究.
- 讨论针对Lp(a) 的新兴疗法及其在亚洲亚组中的相关性.
主要方法:
- 对亚洲人群中Lp (a) 的观测研究和遗传分析进行系统审查.
- 对与亚洲人Lp (a) 水平相关的心血管结局数据的分析.
- 评估目前和新兴的治疗药物用于Lp (a) 减少.
主要成果:
- 升高的Lp (a) 与亚洲人的ASCVD风险增加有关,尽管平均度通常较低.
- 观察性研究将较高的Lp (a) 与亚洲人群中的冠状动脉化,心肌梗塞,中风和复发性心血管事件联系起来.
- 新型疗法,如PCSK9抑制剂,inclisiran和反感性寡核酸,在降低Lp (a) 方面表现有前途.
结论:
- 常规的Lp (a) 测量可以提高心血管风险分层,并指导亚洲人群的治疗决策.
- 了解Lp (a) 的种族差异对于有效预防和管理心血管疾病至关重要.
- 需要进一步的研究和特定人群的指导方针来优化亚洲的针对性治疗.
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