胆固醇和心血管风险在2型糖尿病:功能的作用
Ji-Hyun Kim1, Seung-Hwan Lee1, Kyu Na Lee2
1Division of Endocrinology and Metabolism, Department of Internal Medicine, Seoul St. Mary's Hospital, College of Medicine, The Catholic University of Korea, Seoul, Korea.
Journal of lipid and atherosclerosis
|June 10, 2025
概括
功能显著影响2型糖尿病 (T2DM) 患者心血管疾病 (CVD) 风险. 下功能会增加心血管疾病的风险,即使控制低密度脂蛋白胆固醇 (LDL-C) 水平,强调需要量身定制的管理策略.
科学领域:
- 心脏病学 心脏病学
- 腎臟病學 (nephrology) 是一種醫學專業.
- 内分泌学 在内分泌学.
背景情况:
- 在2型糖尿病 (T2DM) 中,脂质参数,功能和心血管疾病 (CVD) 风险之间的相互作用需要进一步调查.
- 了解这些关联对于优化T2DM患者心血管疾病预防策略至关重要.
研究的目的:
- 评估T2DM患者的脂质参数和心血管疾病风险之间的关联.
- 为了确定不同水平的功能对这种关联的影响.
主要方法:
- 使用韩国国家医疗保险服务数据 (2015-2020) 分析了2,343,882名T2DM患者的大队伍.
- 根据估计的淋巴细胞过率 (eGFR),患者被分为三组:≥60,30-59和<30毫升/分钟/1.73米2.
- 低密度脂蛋白胆固醇 (LDL-C) 水平和心血管疾病发病率在eGFR层中进行了评估.
主要成果:
- 在EGFR≥60mL/min/1.73m2的患者中,CVD风险在LDL-C≥100mg/dL时增加.
- 在EGFR 30-59 mL/min/1.73 m2组中,即使LDL-C<70 mg/dL,心血管疾病风险也增加了43%,并且在LDL-C较高时逐渐增加.
- 患有eGFR<30毫升/分钟/1.73米2的患者面临3.3倍的心血管疾病风险增加,即使LDL-C<70毫克/分升.
结论:
- 在T2DM患者中增加心血管疾病风险的LDL-C值受到功能的影响.
- 功能在调节T2DM中LDL-C和心血管疾病风险之间的关系方面发挥着重要作用.
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