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Updated: Feb 11, 2026

Author Spotlight: Deciphering the Role of ATM in Ataxia-Telangiectasia and the Associated Cerebellar Degeneration
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Published on: December 27, 2024

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通过RNAPII绕过阻断病变损害了转录DNA损伤反应

Carolina P Bañuelos, Lucas D Caeiro, Pradeepkumar R Cingaram

    bioRxiv : the preprint server for biology
    |June 10, 2025
    PubMed
    概括

    这项研究表明,p300蛋白质可以阻止RNA聚合酶II (RNAPII) 绕过DNA损伤. 没有p300,RNAPII会转录受损的DNA,导致基因组不稳定和细胞生长减少.

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