患有自闭症谱系障碍的儿童的肠道微生物群多样性和组成:与症状严重程度的关联
Qinghuang Zeng1,2, Yisheng Hu3,4, Leiying Xie3
1School of Clinical Medicine, Fujian Medical University, Fuzhou, China.
PeerJ
|June 10, 2025
概括
患有自闭症谱系障碍 (ASD) 的儿童的肠道微生物群组成因症状严重程度而异. 较轻微的ASD病例显示肠道细菌更接近神经类型儿童,为潜在的干预提供了洞察力.
科学领域:
- 微生物组研究的研究.
- 神经发育障碍 神经发育障碍
- 儿科卫生健康 儿科卫生健康
背景情况:
- 自闭症谱系障碍 (ASD) 是一种影响社交和沟通技能的神经发育状况.
- 肠道微生物群在自闭症病理生理学中的作用越来越被认可,但尚未完全理解.
- 自闭症症状严重程度与肠道微生物变化之间的具体关系需要进一步研究.
研究的目的:
- 调查肠道微生物组成与儿童自闭症谱系障碍症状严重程度之间的关联.
- 为了比较患有严重ASD,轻度ASD和神经类型儿童的肠道微生物概况.
主要方法:
- 从三组儿童收集了便样本:神经类型,严重的ASD和轻度的ASD.
- 儿童神经病学家评估了ASD症状的严重程度.
- 用高通量测序分析了肠道微生物群的多样性和组成.
主要成果:
- 在严重和轻微的ASD组之间观察到细菌α多样性的显著差异.
- 贝塔多样性分析显示,严重的ASD具有明显的微生物群落,轻微的ASD与神经类型儿童相似.
- 像Firmicutes这样的细菌类和像Ascomycota这样的真菌类的丰度随着ASD的严重程度而变化;功能预测表明严重ASD的代谢途径发生了变化.
结论:
- 肠道微生物群的组成在ASD儿童和神经类型儿童之间有显著差异,与症状严重程度相关.
- 患有较轻度ASD的儿童表现出与神经类型个体更相似的肠道微生物特征.
- 这些发现为ASD病原体和基于微生物组的干预措施的潜在治疗目标提供了宝贵的见解.
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