大麻和认知:人类随机对照试验的文献综述
Jyotpal Singh1, Chase J Ellingson2, M Abdullah Shafiq2
1Faculty of Kinesiology and Health Studies, University of Regina.
Behavioural pharmacology
|June 10, 2025
概括
大麻 (CBD) 可能对健康个体的认知功能和睡眠有轻微的益处. 然而,它在各种神经和精神疾病中对认知的影响是不一致的或最小的,需要在标准化剂量下进行进一步研究.
科学领域:
- 神经科学是一个神经科学.
- 精神病学是一个精神病学.
- 药理学 药理学是指药理学的学科.
背景情况:
- 大麻素 (CBD) 是一种非有毒的植物性大麻素,已显示出改善神经生理功能和主观症状的潜力.
- 对于CBD对不同人群认知功能的影响仍然不完全理解.
研究的目的:
- 系统地审查随机对照试验 (RCT),检查CBD给药对人类认知功能的影响.
- 在健康参与者和患有神经,精神和物质使用障碍的人群中综合发现.
主要方法:
- 在PubMed/Medline上进行了全面的文献搜索,使用与大麻,CBD,认知和RCT相关的关键词.
- 包括36个相关的RCT,包括对健康个体和患有帕金森病,精神疾病,精神病,精神分裂症和物质使用障碍的患者的研究.
主要成果:
- 健康的参与者在各种CBD剂量策略下显示出认知功能和睡眠质量的潜在改善.
- 在特定剂量下,CBD的使用对帕金森病患者的日常活动带来了轻微的改善,并减少了精神病患者的焦虑.
- 认知功能结果在精神病/偏执症中不一致,在精神分裂症中微不足道,即使在高剂量的CBD中,在物质使用障碍中也几乎没有影响.
结论:
- CBD在改善认知功能的有效性是可变的,似乎取决于受研究的人口和剂量.
- 目前的发现受限于急性剂量,剂量变化和施用途径,强调需要标准化的协议和配方来澄清CBD的认知益处.
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