复杂物体的感知歧视:阿波利波蛋白E e4基因剂量对中年人的影响
Claire Lancaster1,2, Sam Berens1, Jessica Daly1
1School of Psychology, University of Sussex, Brighton, UK.
概括
阿波蛋白E (APOE) e4基因剂量影响中年人的感知歧视. APOE44载体显示功能受损,而APOE34载体被保存,这表明早期阿尔茨海默病的风险标志物.
科学领域:
- 神经科学是一个神经科学.
- 遗传学 是一个遗传学.
- 认知心理学 认知心理学
背景情况:
- 复杂的感知歧视依赖于中间叶 (MTL) 区域,特别是围膜皮层.
- 阿波利波蛋白E (APOE) e4等位基因是阿尔茨海默病 (AD) 的重要遗传风险因素.
研究的目的:
- 调查APOE e4对中年成人感知歧视能力的基因剂量影响.
- 确定APOE e4是否影响中年MTL功能和认知表现.
主要方法:
- 351名年龄在45-65岁的成年人被按APOE e4基因剂量分组:APOE33 (n=142),APOE34 (n=135) 和APOE44 (n=36).
- 参与者完成了格里布尔的"奇怪的"感知歧视任务.
主要成果:
- 与APOE33和APOE34个体相比,APOE44载体在感知判断中的准确性明显较低.
- 在反应速度方面观察到年龄和APOE e4基因剂量之间存在显著的相互作用,与年龄相关的减速随着e4等位基因数量的增加而增加.
- 估计表明,APOE44载体在54岁之前比APOE33个体更快,之后它们变得更慢.
结论:
- 在APOE44载体中受损的感知歧视表明中年时MTL功能受到损害,可能与加速的tau聚合有关.
- 感知歧视任务可以作为阿尔茨海默病风险的早期指标.
- APOE34携带者在中年期表现出保留的感知歧视,表明相对受保护的MTL功能.
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