假设祖先的真核生物在没有kinetochores或线粒分裂的情况下发生性繁殖
1Institute of Cell Biology, School of Biological Sciences, University of Edinburgh, Max Born Crescent, Edinburgh EH9 3BF, UK.
Journal of cell science
|June 10, 2025
概括
这项研究挑战了从线粒分裂进化而来的半变异的教条. 它提出,最后一个真核的共同祖先缺乏kinetochores,两种系统独立进化,和半半变异发生在线粒变异之前.
科学领域:
- 细胞生物学 细胞生物学
- 进化生物学 进化生物学
- 遗传学 是一个遗传学.
背景情况:
- 类真核生物在遗传传输过程中使用线粒分裂和半分裂.
- 分解是普遍的,这导致了假设它早于半转化.
- 在这两种过程中,动态基因对染色体分离至关重要.
研究的目的:
- 提出关于动态细胞和真核细胞分裂进化的新假设.
- 挑战已经确立的,从线粒分裂进化而来的半分裂的观点.
主要方法:
- 进化关系的假设驱动分析.
- 基因组蛋白质的比较基因组学.
- 在早期的真核生物中重新评估细胞融合和基因交换.
主要成果:
- 最后一个真核生物共同祖先 (LECA) 很可能缺乏动态.
- 进化了两个独立的动态系统:一个在动态类动物中,另一个在其他真核生物中.
- 梅奥斯可能在线粒分裂之前进化了关键方面.
结论:
- 线粒分裂和半分裂的进化比以前所认为的要复杂得多.
- 动态的多样性反映了独立的进化轨迹.
- 梅奥斯可能是一个比线粒分裂更古老的过程,起源于LECA之前.
相关概念视频
Meiosis vs. Mitosis
58.4K
Cell division is necessary for growth and reproduction in organisms. Mitosis aids cell growth and development by dividing somatic cells. In contrast, meiosis causes the division of germ cells and plays an essential role in sexual reproduction. Due to their unique functional requirements, mitosis and meiosis differ from each other in multiple aspects.
Before the start of mitosis and meiosis I, the cell synthesizes DNA, resulting in two homologous copies of each chromosome. DNA synthesis is...
Before the start of mitosis and meiosis I, the cell synthesizes DNA, resulting in two homologous copies of each chromosome. DNA synthesis is...
58.4K
Eukaryotic Evolution
36.9K
The endosymbiont theory is the most widely accepted theory of eukaryotic evolution; however, its progression is still somewhat debated. According to the nucleus-first hypothesis, the ancestral prokaryote first evolved a membrane to enclose DNA and form the nucleus. Conversely, the mitochondria-first hypothesis suggests that the nucleus was formed after endosymbiosis of mitochondria.
Contrary to the endosymbiont theory, the eukaryote-first hypothesis proposes that the simpler prokaryotic and...
Contrary to the endosymbiont theory, the eukaryote-first hypothesis proposes that the simpler prokaryotic and...
36.9K
Meiosis I
194.7K
Meiosis is a carefully orchestrated set of cell divisions, the goal of which—in humans—is to produce haploid sperm or eggs, each containing half the number of chromosomes present in somatic cells elsewhere in the body. Meiosis I is the first such division, and involves several key steps, among them: condensation of replicated chromosomes in diploid cells; the pairing of homologous chromosomes and their exchange of information; and finally, the separation of homologous chromosomes by...
194.7K
Meiosis II
46.4K
Meiosis II entails cell division and segregation of the sister chromatids, resulting in the production of four unique haploid gametes. The steps for meiosis II are similar to mitosis, except that meiosis II occurs in haploid cells, whereas mitosis occurs in diploid cells.
The timing and cell division patterns of meiosis differ between males and females. In male meiosis, the centrosomes are part of the formation of the meiotic spindle. However, in oocytes, including that of humans, Drosophila,...
The timing and cell division patterns of meiosis differ between males and females. In male meiosis, the centrosomes are part of the formation of the meiotic spindle. However, in oocytes, including that of humans, Drosophila,...
46.4K
Separation of Sister Chromatids
3.8K
At the transition from prophase to metaphase, there is a reduction in cohesion along the chromosomal arms, resulting in the resolution of sister chromatids. However, residual cohesin connections remain to hold the sister chromatids together until the transition from metaphase to anaphase. The residual connection prevents any premature separation of sister chromatids, blocking the risks of aneuploidy within the daughter cells.
At the onset of anaphase, separase, a proteolytic enzyme, is...
At the onset of anaphase, separase, a proteolytic enzyme, is...
3.8K
Centrioles and Centrosomes
3.6K
Most animal cells comprise a pair of centrioles together called a centrosome. The cell duplicates its centrosome and contains two centrosomes side-by-side, which begin to move apart during the prophase. As the centrosomes migrate to two different sides of the cell, microtubules start extending from each centrosome toward the other end. The mitotic spindle is composed of the centrosomes and their emerging microtubules.
Near the end of the prophase, also called late prophase or...
Near the end of the prophase, also called late prophase or...
3.6K


