儿科侵入性肺炎球菌疾病谱在第三代肺炎球菌结合体疫苗实施之前
Corinne Levy1,2,3,4,5, Aude Estivaux3,4,6, Emmanuelle Varon1,3,4,7
1ACTIV, Association Clinique et Thérapeutique Infantile du Val-de-Marne, 94000 Créteil, France.
Journal of the Pediatric Infectious Diseases Society
|June 10, 2025
概括
侵入性肺炎球菌疾病 (IPD) 病例在PCV13之后转移,24F血清型现在是最常见的. 像PCV20这样的新型疫苗覆盖了更多的血清型,包括与致命的IPD病例相关的血清型.
科学领域:
- 儿科 儿科 儿科
- 传染性疾病 传染性疾病
- 疫苗学 疫苗学 疫苗学
背景情况:
- 肺炎球菌联合疫苗 (PCV) 改变了侵入性肺炎球菌疾病 (IPD) 的风景.
- 在PCV实施后,观察到IPD血清型分布和临床表现的变化.
- 本研究研究了PCV13引入15年后的IPD,在下一代PCV之前.
研究的目的:
- 描述儿童侵袭性肺炎球菌病 (IPD) 的临床特征.
- 为了确定IPD病例的血清型分布.
- 评估PCV13的影响和新型疫苗 (PCV15,PCV20) 的潜在覆盖率.
主要方法:
- 在法国128个儿科病房 (2017-2022) 进行IPD病例的前性监测.
- 数据收集包括人口统计,临床数据,风险因素和结果.
- IPD病例被分为脑膜炎,无源细菌病,细菌性肺炎和其他IPD.
主要成果:
- 脑膜炎是最常见的临床实体 (36.4%),其次是无源细菌病 (31.6%).
- 血清型24F是最常见的整体 (16.4%),PCV20非PCV13血清型与死亡的显著比例 (33.3%) 相关.
- PCV13血清型 (3,19A,19F) 仍占病例的15.0%,而PCV20提供了比PCV13和PCV15.5更广泛的覆盖范围.
结论:
- 在本研究中,IPD的主要原因是24F血清型,目前的第三代PCV不涵盖.
- 与PCV13和PCV15相比,PCV20的血清型覆盖率增加,这可能会影响死亡率.
- 了解不断变化的血清型分布对于优化肺炎球菌疫苗接种策略至关重要.
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