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多菌株益生菌通过肠肝轴调节减弱2型糖尿病大鼠的碳水化合物-脂质代谢失调
Yecheng Gao1,2,3,4, Yanfang Liu1,2,3, Zelong Li1,2,3
1Inner Mongolia Key Laboratory of Dairy Biotechnology and Engineering, Inner Mongolia Agricultural University, Hohhot, Inner Mongolia, China.
mSystems
|June 10, 2025
概括
多菌株益生菌显著改善了2型糖尿病 (T2DM) 鼠的血糖和脂质概况. 这项研究强调了益生菌.
科学领域:
- 代谢障碍 代谢障碍 代谢障碍
- 肠道微生物组研究研究
- 益生菌疗法是一种益生菌疗法.
背景情况:
- 2型糖尿病 (T2DM) 是一种慢性代谢障碍,对患者的健康有重大影响.
- 管理T2DM并发症和相关的失脂症仍然是一个临床挑战.
- 益生菌正在被探索为潜在的治疗策略对代谢疾病.
研究的目的:
- 在T2DM大鼠模型中研究多菌株益生菌补充对碳水化合物和脂质代谢的影响.
- 阐明肠肝轴在介导T2DM上的益生菌效应中的作用.
- 确定益生菌在改善代谢概况方面的剂量依赖性疗效.
主要方法:
- 建立T2DM大鼠模型并随机分配到对照,T2DM,低剂量益生菌和高剂量益生菌组.
- 64天内使用多菌株益生菌配方 (3种Lacticaseibacillus,一种Bifidobacterium).
- 对血糖和脂质资料,肠道微生物组成,便短链脂肪酸,血清胆汁酸以及肝/肠道转录基因通路的全面分析.
主要成果:
- 高剂量的益生菌补充剂显著改善了T2DM大鼠的血糖和脂质概况.
- 益生菌干预调节了肠道微生物群的多样性和组成,丰富了有益细菌.
- 多omics数据表明,短链脂肪酸和胆酸在T2DM中介于肠肝交叉.
结论:
- 多菌株益生菌在管理T2DM相关的代谢失调方面显示出显著的治疗潜力.
- 益生菌的有效性取决于剂量,更高的剂量产生更明显的益处.
- 肠肝轴在T2DM中益生菌的代谢效益中起着至关重要的作用.
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