在Mycobacterium abscessus水中分离的消毒剂和抗生素耐药性
Kirby Patterson-Fahy1, Robyn Carter1, Steven L Taylor2,3
1The University of Queensland, Greenslopes Clinical School, Gallipoli Medical Research, Greenslopes, Queensland, Australia.
Microbiology spectrum
|June 10, 2025
概括
饮用水中的Mycobacterium abscessus对和胺具有很高的抗性. 接触消毒剂可能会增加抗生素耐药性,可能导致感染率上升.
科学领域:
- 环境微生物学环境微生物学
- 抗微生物耐药性 抗微生物耐药性
背景情况:
- 全球饮用水中发现了Mycobacterium abscessus,感染率正在上升.
- 虽然通常是通过环境获得的,但环境选择性压力对M. abscessus进化的影响还未得到充分研究.
研究的目的:
- 调查饮用水中的M. abscessus对消毒剂和抗生素的敏感性.
- 评估和胺暴露对M. abscessus耐药性的影响.
主要方法:
- 对2007年,2017-2018年和2021-2022年从饮用水中收集的M. abscessus分离物的分析.
- 实验室进化实验使M. abscessus暴露在和胺中.
主要成果:
- 在水隔离物中没有观察到消毒剂或抗生素耐药性的时间趋势.
- M. abscessus分离物比更容易受到胺的影响,但两者都超过了处理度.
- 实验室进化诱导的耐药性 (非遗传性) 和胺暴露降低了伊米佩内姆的敏感性.
结论:
- 菌根菌 (Mycobacterium abscessus) 对常见的饮用水消毒剂具有很高的抵抗力.
- 暴露在水系统中的消毒剂可能会影响抗菌素易感性,可能导致疾病频率增加.
相关概念视频
01:30Development of Antibiotic Resistance
242
Antibiotic resistance is a major public health concern that arises when bacteria evolve mechanisms to withstand the effects of antibiotic treatments. This resistance can be intrinsic, acquired through genetic mutations, or transferred between bacteria via horizontal gene transfer. The development of antibiotic resistance poses significant challenges in treating bacterial infections and necessitates ongoing research to develop new therapeutic strategies.Intrinsic resistance occurs when bacterial...
242
01:31Defense Against Bacterial Pathogens
1.5K
The human immune system is a complex network of cells, tissues, and organs that work together to defend the body against bacterial infections. It consists of various immune cells, each playing a specific role in the defense mechanism.
Phagocytes
Phagocytes are the frontline soldiers of the immune system. They include neutrophils and macrophages. Neutrophils are the most abundant type of white blood cell and are quickly mobilized to the site of infection. Macrophages are larger cells that patrol...
Phagocytes
Phagocytes are the frontline soldiers of the immune system. They include neutrophils and macrophages. Neutrophils are the most abundant type of white blood cell and are quickly mobilized to the site of infection. Macrophages are larger cells that patrol...
1.5K
01:28Antimicrobial Effectiveness
175
The effectiveness of antimicrobial agents depends on various factors influencing their ability to eliminate microbial populations. Larger microbial populations require more time for complete eradication, emphasizing the importance of population size analysis when evaluating antimicrobial efficacy.Microbial resistance to antimicrobial agents varies significantly. Highly resilient microorganisms include endospores, gram-negative bacteria, and non-enveloped viruses, while prions are exceptionally...
175