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重新利用一种药物来惩罚耐卡巴胺的Acinetobacter baumannii

Jennifer M Colquhoun1, Carter U Brzezinski2, Andrew Ji1

  • 1Research Service, Atlanta VA Medical Center, Decatur, GA 30033.

Proceedings of the National Academy of Sciences of the United States of America
|June 10, 2025
PubMed
概括

芬迪林是一种FDA批准的药物,通过抑制必需的脂蛋白贩运 (Lol) 途径,对抗卡巴耐药的Acinetobacter baumannii表现出抗菌活性. 这一发现将卡巴胺耐药性与Lol通路压力联系在一起,为抗生素开发提供了新的途径.

关键词:
这种细菌是Acinetobacter baumannii.在OXAβ-乳糖酶中,OXAβ-乳糖酶是抗生素耐药性 抗生素耐药性药物重用是为了改变药物的用途.芬迪林 (fendiline) 是一种可怕的药物.

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