通过口服输送的抗氧化剂纳米来直接调节宿主细胞和肠道微生物群,用于结肠炎治疗
Jingwen Xie1, Jingxing Si2, Yuping Chen1,2
1Zhejiang Key Laboratory of Smart Biomaterials and Center for Bionanoengineering, College of Chemical and Biological Engineering, Zhejiang University, Hangzhou, Zhejiang 310058, China.
一种新的口服纳米系统通过向肠道炎症,屏障功能障碍和微生物失衡,提供抗氧化酶来治疗性结肠炎 (UC). 这种方法有效地修复了肠道,并在临床前模型中恢复了平衡.
科学领域:
- 胃肠病学 胃肠病学
- 纳米技术纳米技术
- 生物医学工程 生物医学工程
背景情况:
- 性结肠炎 (UC) 的特点是炎症,肠道屏障受损和肠道失生症,由活性氧物种 (ROS) 恶化.
- 目前的治疗方法很难解决UC的多面性质,包括宿主微生物相互作用和氧化应激.
研究的目的:
- 开发一种可口服的纳米系统,用于同时治疗UC中的免疫失调,上皮损伤和微生物失衡.
- 为了研究抗氧化酶载荷的纳米的治疗潜力,针对宿主细胞和肠道微生物群.
主要方法:
- 基于聚二氧化氨酸 (PTAO) 的工艺化zwitterionic纳米,配有ROS-labile交叉链接器,用于目标货物交付.
- 设计用于胃肠道中路稳定性和ROS触发的炎症部位释放的纳米.
- 在性结肠炎和急性辐射结肠炎的小鼠模型中进行评估.
主要成果:
- 纳米成功地将抗氧化酶传递给肠道上皮细胞,巨细胞和肠道微生物.
- 通过内部化纳米进行ROS清理,促进了上皮细胞的修复和巨细胞的再极化.
- PTAO外促进了酶传递到细菌中,恢复了微生物平衡,减少了氧化损伤.
- 该系统显著缓解了炎症,恢复了肠道平衡,并在结肠炎模型中减少了结肠损伤.
结论:
- 开发的多功能纳米系统为性结肠炎提供了一个有前途的口腔治疗策略.
- 同时针对宿主和微生物因素,代表了结肠炎治疗的重大进步.
更多相关视频
08:58Analyzing Beneficial Effects of Nutritional Supplements on Intestinal Epithelial Barrier Functions During Experimental Colitis
Published on: January 5, 2017
08:53Investigating the Alleviating Effects of Bacillus cereus Administration on Colitis through Gut Microbiota Modulation
Published on: July 27, 2022
相关概念视频
Drugs for Peptic Ulcer Disease: Sucralfate as Mucosal Protective Agents
In this scenario, mucosal protective agents like sucralfate play an essential role. Sucralfate, a complex of sulfated sucrose and aluminum hydroxide, demonstrates its usefulness in acidic conditions,...
Drugs for Peptic Ulcer Disease: Prostaglandin Analogs as Mucosal Protective Agents
Non-steroidal anti-inflammatory drugs (NSAIDs) can induce peptic ulcers by inhibiting cyclooxygenase, decreasing...
Drugs for Treatment of Ulcerative Colitis in IBD
Drugs for Treatment of Crohn's Disease in IBD Using Immunomodulatory Agents
Peptic Ulcer Disease IV: Management
The therapeutic approach involves ensuring adequate rest, implementing drug therapy, promoting smoking cessation, making dietary modifications, and emphasizing long-term follow-up care.
Pharmacological management
The prevailing therapy for peptic ulcers involves a combination of managing the patient's current...
Inflammatory Bowel Disease IV: Pharmacological Management
Pharmacologic...
