[达拉图穆马布,卡菲尔佐米布和波马利多米德在复发性多发性髓瘤患者中的使用:当前的高效治疗方法]
Francisco Samaniego E1, Guillermo Conte L1
1Hematología, Hospital Clínico Universidad de Chile, Santiago, Chile.
概括
用达拉图穆马布,卡菲尔佐米布和波马利多米德进行的救援治疗在智利的复发性或耐药性多发性髓瘤患者中显示出有效性和安全性. 这些发现支持对多发性骨髓瘤这些先进疗法的更广泛使用.
科学领域:
- 血液学 血液学 血液学
- 在瘤学瘤学.
- 临床药理学 临床药理学
背景情况:
- 多发性骨髓瘤 (MM) 是一种血细胞恶性瘤,尽管治疗进展,但复发率很高.
- 目前的MM疗法可以改善存活率,但不能治愈,需要有效的救援治疗.
- 关于智利新型MM救援方案的有效性和安全性的数据有限.
研究的目的:
- 评估达拉图穆马布,卡菲尔佐米布和基于玛利多米德的救援治疗的有效性和安全性.
- 评估在智利大学临床医院治疗复发性或耐药性多发性骨髓瘤 (RRMM) 患者的结果.
- 为国家医疗保健政策提供有关MM治疗准入的相关数据.
主要方法:
- 对18岁以上的RRMM患者进行了回顾性描述性研究.
- 包括接受达拉图穆马布,卡菲尔佐米布和/或波马利多米德治疗方案的患者.
- 从电子医疗记录中分析反应率,无进展生存率 (PFS),总生存率 (OS) 和不良事件.
主要成果:
- 包括15名RRMM患者,平均年龄67岁,中位数为3个先前的治疗线.
- 对莱纳利多米德 (86.6%) 和博特佐米布 (46.6%) 的高耐火率.
- 响应率:6.6%的病情稳定,26.6%的部分响应,53.3%的非常好的部分响应,13.3%的完整响应. 中位数PFS为20个月;没有达到OS. 常见的不良事件包括感染和输液反应.
结论:
- 达拉图穆马布,卡菲尔佐米布和/或波马利多米德是重度预治疗RRMM患者的有效和安全的救援选择.
- 与国际数据相比,观察到有利的PFS和OS,尽管反应不那么深刻.
- 结果支持在智利国家卫生系统内倡导这些先进的MM疗法.
更多相关视频
09:34Dynamic Imaging of Chimeric Antigen Receptor T Cells with [18F]Tetrafluoroborate Positron Emission Tomography/Computed Tomography
Published on: February 17, 2022
3.3K
07:24Repression of Multiple Myeloma Cell Growth In Vivo by Single-wall Carbon Nanotube SWCNT-delivered MALAT1 Antisense Oligos
Published on: December 13, 2018
6.4K
相关概念视频
Tumor Immunotherapy
489
Immunotherapy is a treatment that boosts or manipulates the immune system to fight diseases, including cancer. For instance, by stimulating an immune response through vaccinations against viruses that cause cancers, like hepatitis B virus and human papillomavirus, these diseases can be prevented. Nonetheless, some cancer cells can avoid the immune system due to their rapid mutation and division. The immune response to many cancers involves three phases: elimination, equilibrium, and escape.
489
Targeted Cancer Therapies
7.5K
The targeted cancer therapies, also known as “molecular targeted therapies,” take advantage of the molecular and genetic differences between the cancer cells and the normal cells. It needs a thorough understanding of the cancer cells to develop drugs that can target specific molecular aspects that drive the growth, progression, and spread of cancer cells without affecting the growth and survival of other normal cells in the body.
There are several types of targeted therapies against...
There are several types of targeted therapies against...
7.5K
Combination Therapies and Personalized Medicine
4.9K
Combining two or more treatment methods increases the life span of cancer patients while reducing damage to vital organs or tissue from the overuse of a single treatment. Combination therapy also targets different cancer-inducing pathways, thus reducing the chances of developing resistance to treatment.
The combination of the drug acetazolamide and sulforaphane is a good example of combination therapy to treat cancer. The cells in the interior of a large tumor often die due to the hypoxic and...
The combination of the drug acetazolamide and sulforaphane is a good example of combination therapy to treat cancer. The cells in the interior of a large tumor often die due to the hypoxic and...
4.9K
Drugs that Stabilize Microtubules
2.0K
Microtubules are dynamic structures that undergo cycles of catastrophe and rescue. The microtubules play a central role in cell division by forming the spindle apparatus for segregating the chromosomes. This makes them ideal targets for regulating dividing cells in tumors and malignant cancer cells. Microtubule stabilizing drugs help stabilize the microtubule formation and promote its polymerization. Paclitaxel was the first microtubule stabilizing agent used as anticancer drug in chemotherapy...
2.0K
Treatment Resistant Cancers
3.3K
Cancer is the second leading cause of death in the United States. A cancer cell is genetically unstable and hence can mutate faster. They can also modify their microenvironment and escape immune surveillance. The difficulties in treating cancer are further compounded by the emergence of rapid resistance to anticancer drugs. The most common ways to attain resistance in cancer cells include alteration in drug transport and metabolism, modification of drug target, elevated DNA damage response, or...
3.3K
