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儿童白血病的关键并发症:中性增殖性肠球炎,危险因素和结果
Ayca Koca Yozgat1, Rabia D Kilçik2, Selin Çetin2
1Departments of Pediatric Hematology-Oncology.
Journal of pediatric hematology/oncology
|June 10, 2025
概括
伤寒炎,或中性贫血性肠球炎,是儿童白血病患者的严重并发症,经常出现腹痛和发烧. 早期诊断和多学科护理对于管理这种情况和改善结果至关重要.
科学领域:
- 胃肠病学 胃肠病学
- 儿科瘤学 儿科瘤学
- 传染性疾病 传染性疾病
背景情况:
- 中性发育性肠球炎 (型炎) 是在接受化疗的儿科患者的严重胃肠道并发症.
- 它的特点是眼膜和远端膜的炎症,经常出现发烧,腹部疼痛和中性质衰竭.
研究的目的:
- 描述临床特征,成像检测结果和儿童白血病患者的伤寒炎的危险因素.
- 突出诊断标准和管理策略,为伤寒炎在这个脆弱的人群.
主要方法:
- 一项回顾性研究评估了72名患有白血病的儿童患者,在2019年8月至2023年3月期间被诊断患有伤寒炎.
- 诊断是基于中性质减退,临床症状和成像 (眼壁厚度在超声波上>3毫米).
- 收集的数据包括人口统计,化疗,临床表现,培养,成像,并发病,住院,管理和死亡率.
主要成果:
- 伤寒炎的发病率为36%,常见症状包括腹痛 (81.8%) 和发烧 (48.1%).
- 克莱布塞拉肺炎是分离的最常见的生物体. 眼膜和末端膜受影响最大 (37.7%),平均壁厚为4.6±1.7毫米.
- 抗生素治疗的中位数为13天;化疗恢复延迟了13.6±15.5天. 5%的患者 (4/72) 死于伤寒炎和败血症.
结论:
- 中性增殖性肠球炎是儿童白血病患者的重大临床挑战.
- 早期怀疑,及时诊断和多学科的方法对于有效的管理至关重要.
- 中性衰竭患者的胃肠道症状需要对伤寒炎进行彻底的调查.
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