重症新生儿发病率和全因和因特定死亡率在婴儿期和青春期晚期
Hillary Graham1, Kari Johansson1, Martina Persson2
1Clinical Epidemiology Division, Department of Medicine Solna, Karolinska Institutet, Stockholm, Sweden.
JAMA pediatrics
|June 10, 2025
概括
重度新生儿发病率 (SNM) 显著增加了儿童死亡风险. 早期识别和长期照顾SNM婴儿对于降低死亡率至关重要.
科学领域:
- 新生儿科学 新生儿科学
- 儿科死亡率 儿科死亡率
- 流行病学 流行病学
背景情况:
- 重症新生儿发病率 (SNM) 与早期死亡率有关,但长期影响尚不清楚.
- 了解这些关联对于改善儿童存活率至关重要.
- 这项研究调查了SNM对死亡率的扩展影响.
研究的目的:
- 检查重症新生儿发病率 (SNM) 与全因和因特定死亡率之间的关联.
- 追踪与新生儿健康有关的从婴儿期到青春期末的死亡率.
- 确定与SNM相关的特定死亡原因.
主要方法:
- 在瑞典进行基于人口的队列研究 (2,098,752名新生儿).
- 随访时间从28天到21.2年,分析死亡率数据.
- 使用了考克斯比例危险模型和兄弟对照分析.
主要成果:
- 患有SNM的儿童死亡风险增加了5.92倍 (aHR 5.92).
- 新生儿神经疾病与死亡率的相关性最高 (aHR 17.67).
- SNM增加了感染和系统性疾病的死亡风险,女性和按期出生的婴儿的风险更高.
结论:
- 严重的新生儿发病率是儿童死亡率的重要风险因素.
- 预防SNM和提供早期的长期随访护理可以降低死亡率.
- 研究结果强调需要对患有新生儿健康问题的儿童进行持续监测.
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