晚期大脑衰老,灰质的选择性脆弱性,以及帕金森病中的认知能力
Mengfei Cai1,2, Chentao He2, Hao Li3
1Guangdong Cardiovascular Institute, Guangdong Provincial People's Hospital (Guangdong Academy of Medical Sciences), Southern Medical University, Guangzhou, China.
概括
帕金森病 (PD) 患者的大脑预测年龄差异 (PAD) 突出显示了脆弱的大脑区域,并预测了认知能力下降. 这一发现有助于识别患轻度认知障碍 (MCI) 风险较高的人.
科学领域:
- 神经成像是一种神经成像.
- 老年学是一门学科.
- 神经学 神经学
背景情况:
- 帕金森病 (PD) 与加速的大脑衰老有关.
- 识别易受伤害的大脑区域和认知相关物对于理解PD进展至关重要.
研究的目的:
- 确定灰质区域最受PD中高级大脑衰老影响.
- 为了检查脑衰老和PD患者的认知功能之间的关系.
- 根据大脑衰老标志物评估轻度认知障碍 (MCI) 转换的风险.
主要方法:
- 利用了来自帕金森病进展标记计划 (PPMI) 队列中的125名早期PD患者的结构MRI,扩散MRI和DAT-SPECT数据.
- 在5年内每年评估认知功能,并在1,2,4年进行神经成像随访.
- 采用线性回归,线性混合效应模型和Cox比例危险模型来分析大脑预测年龄差 (PAD),免费水,认知和MCI转换风险.
主要成果:
- 大脑PAD在PD患者中随着时间的推移表现出非线性进展模式.
- 易受伤害的大脑区域包括皮质,条纹体,海马和胆固醇基底前脑,显示与自由水的差异关联.
- 基线大脑PAD与认知缺陷相关,并预测了转化为MCI的5年风险.
结论:
- 大脑PAD可以作为一种有价值的工具来识别PD中易受加速衰老的脑部区域.
- 大脑PAD可以帮助识别患有轻度认知障碍 (MCI) 风险增加的PD患者.
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