锡林丁通过调节Nrf2/Keap-1,TLR4/HMGB1/RAGE和NF-κB通路来改善硫酸诱导的功能障碍
Hassan M Otifi1, Muhammad Faisal Hayat2, Ali Akbar2
1Department of pathology, College of Medicine, King Khalid University, P.O. 641, Abha 61421, Saudi Arabia.
Tissue & cell
|June 10, 2025
概括
赛灵丁 (SGN) 保护大鼠免受硫酸 (TLM) 诱导的损伤. 补充SGN可以减少炎症,氧化应激和亡,改善整体脏健康.
科学领域:
- 毒理学 毒理学 毒理学
- 药理学 药理学是指药理学的学科.
- 生物化学 生物化学
背景情况:
- 硫酸 (TLM) 是一种具有毒性的重金属,可引起严重的损伤.
- 赛灵丁 (SGN) 是一种天然的多,具有已知的药用特性.
- 了解SGN对TLM诱导毒性的保护机制对于潜在的治疗应用至关重要.
研究的目的:
- 在大鼠模型中研究素 (SGN) 对硫酸 (TLM) 诱导的毒性产生的性保护作用.
- 评估SGN对氧化应激,炎症,亡和TLM暴露后脏组织学变化的影响.
主要方法:
- 32只Sprague Dawley大鼠被分为四组:对照组,TLM组,TLM+SGN组和单独的SGN组.
- TLM是以6.4mg/kg,SGN是以10mg/kg的剂量进行的.
- 评估包括氧化应激标志物 (ROS,MDA,GSH,抗氧化酶),炎症标志物 (MYD88,TLR4,IL-1β,TNF-α,NF-κB的mRNA表达),亡标志物 (Bax,Caspase-3,Caspase-9,Bcl-2),功能标志物 (BUN,肌素,KIM-1,NGAL) 和组织形态学.
主要成果:
- 暴露于TLM显著增加了炎,氧化应激和亡,由改变的基因表达,增加的ROS/MDA,减少的抗氧化能力和增加的亲亡标记物证明.
- TLM中毒导致损伤的血清标志物增加 (BUN,肌素,KIM-1,NGAL) 和功能受损 (肌素清除减少).
- 补充SGN显著改善了TLM诱导的损伤,通过恢复氧化平衡,抑制炎症和亡途径,改善组织形态.
结论:
- 赛灵丁 (SGN) 具有显著的脏保护性质,可以预防硫酸盐 (TLM) 诱导的小鼠脏毒性.
- SGN通过减少氧化应激,抑制炎症反应和预防亡来减轻TLM的毒性.
- 这些发现表明SGN是重金属诱导毒性的潜在治疗剂.
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