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Updated: Jun 12, 2025

Site Specific Lysine Acetylation of Histones for Nucleosome Reconstitution using Genetic Code Expansion in Escherichia coli
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向IDH2通过表观遗传激活cGAS-STING通路来促进抗瘤免疫力

Jiang-Jiang Li1, Xinghua Zhen1, Lulu Liu1

  • 1Zhejiang Provincial Key Laboratory of Pancreatic Disease, The First Affiliated Hospital, Zhejiang University School of Medicine, Hangzhou, Zhejiang 310003, China.

Lung cancer (Amsterdam, Netherlands)
|June 10, 2025
PubMed
概括

异酸脱酶2 (IDH2) 表达与肺癌和乳腺癌中的CD8+ T细胞有负相关性. 抑制IDH2通过通过STING激活I型干扰素途径来增强抗瘤免疫力.

关键词:
酸 (adenosine triphosphate) 是一种 ATP 的一种化合物.CD8 (((+) T细胞是T细胞中的一个.异酸脱酶2 (IDH2) 的同位素.干扰素反应的刺激器CGAMP交互器1 (STING)这是一种I型干扰子.α-基格酸盐的使用.

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