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Updated: Jun 12, 2025

An Explant Assay for Assessing Cellular Behavior of the Cranial Mesenchyme
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An Explant Assay for Assessing Cellular Behavior of the Cranial Mesenchyme

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中枢神经系统中的ECM机制 中枢神经系统形态发生 形态发生

Alessandra Gentile, Katerina Stavropoulou, Katherine R Long

    Developmental neuroscience
    |June 10, 2025
    PubMed
    概括

    细胞外基质 (ECM) 和它的机械特性在中枢神经系统 (CNS) 发育中起着至关重要的作用. 本综述强调了ECM和细胞外力量在中枢神经系统形态发生过程中的积极贡献.

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    Neurulation is the embryological process which forms the precursors of the central nervous system and occurs after gastrulation has established the three primary cell layers of the embryo: ectoderm, mesoderm, and endoderm. In humans, the majority of this system is formed via primary neurulation, in which the central portion of the ectoderm—originally appearing as a flat sheet of cells—folds upwards and inwards, sealing off to form a hollow neural tube. As development proceeds, the...
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