在新生儿中,微生物源的因素可保护CD8+ T细胞应对流感
Joseph Stevens1, Erica Culberson1, Jeremy Kinder2
1Department of Pediatrics, University of Cincinnati College of Medicine, Cincinnati, OH, USA; Division of Neonatology, Cincinnati Children's Hospital Medical Center, Cincinnati, OH, USA; Medical Scientist Training Program, University of Cincinnati College of Medicine, Cincinnati, OH, USA; Immunology Graduate Program, Cincinnati Children's Hospital Medical Center, Cincinnati, OH, USA.
在生命早期使用抗生素可以通过破坏肠道细菌和降低素水平来削弱婴儿对流感的免疫力. 恢复氨基酸可促进T细胞的反应,并防止呼吸道感染.
科学领域:
- 免疫学
- 微生物学
- 代谢途径
背景情况:
- 早期的呼吸道病毒感染对公众健康构成重大挑战.
- 婴儿易受感染的机制尚未完全理解.
研究的目的:
- 研究抗生素诱导的肠道失调如何影响婴儿的流感特异性CD8+T细胞免疫力.
- 确定连接肠道微生物群,新陈代谢和抗病毒防御的分子途径.
主要方法:
- 使用小鼠模型和人类婴儿样本.
- 评估了CD8+ T细胞反应,基因表达和代谢物水平 (氨酸).
- 研究了核因子3 (NFIL3) 和T细胞因子1 (TCF1) 的作用.
主要成果:
- 抗生素诱导的失生症通过降低氨酸水平损害了CD8+ T细胞免疫力.
- 干扰了TCF1的NFIL3依赖性表观遗传调节,影响了T细胞功能.
- 双菌殖民和素补充恢复了T细胞的反应和保护.
结论:
- 早期的微生物群落极大地影响了抗病毒免疫力.
- 通过素进行肠肺代谢通信对于婴儿的呼吸系统防御至关重要.
- 伊诺辛是增强婴儿对呼吸系统病毒免疫力的潜在治疗点.
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