相关实验视频

Updated: May 5, 2026

Author Spotlight: A Focus on Standardized Salivary Gland Ultrasound Protocol in Connective Tissue Disease Research

Author Spotlight: A Focus on Standardized Salivary Gland Ultrasound Protocol in Connective Tissue Disease Research

Published on: October 13, 2023

CircRSF1:一个潜在的诊断生物标志物,用于原发性Sjögren综合征

Yuqun Wang¹, Honglei Ma², Linping Du²

¹Department of Rheumatology and Immunology, Shandong Province Rheumatic Disease Key Speciality, Affiliated Hospital of Shandong Second Medical University, Weifang, China; Key Laboratory of Rheumatology and Immunology, Weifang, China; School of Public Health, Shandong Second Medical University, Weifang, China; Department of Clinical Research Center, Affiliated Hospital of Shandong Second Medical University, Weifang, China.

|June 10, 2025

概括

循环RNAs (circRNAs) 与自身免疫性疾病有关. 这项研究确定了CircRSF1作为一次性Sjögren中显著下调的circRNA.

科学领域:

免疫学免疫学免疫学
基因组学就是基因组学.
分子生物学分子生物学

背景情况:

异常的循环RNA (circRNA) 表达与自身免疫性疾病有关.
在原发性Sjögren综合征 (pSS) 发病过程中,circRNAs的作用在很大程度上是未知的.
了解pSS中的circRNA对于临床见解至关重要.

研究的目的:

确定与初级Sjögren综合征 (pSS) 相关的新型circRNAs.
阐明已识别的circRNAs的潜在作用机制.
评估pSS中circRNAs的诊断潜力.

主要方法:

高通量测序和RT-qPCR确定了差异表达的circRNAs.
特别分析了Hsa_circ_0000344 (CircRSF1). 这是一个非常好的例子.
接收器操作特征 (ROC) 曲线分析评估了诊断意义.
生物信息学工具预测了分子相互作用和功能.

主要成果:

在pSS中发现了335个差异表达的circRNA.
在pSS患者的外周血液单核细胞 (PBMC) 和唇部唾液腺 (LSG) 中,CircRSF1的下调显著.
ROC分析证实了CircRSF1对pSS诊断的临床相关性.

结论:

这项研究提供了pSS.pSS的circRNA转录形状.
在pSS中,CircRSF1被确定为显著表达不足的circRNA.
CircRSF1显示出作为pSS的新型诊断生物标志物的潜力.

关键词:

生物标志物生物标志物循环RSF1 的情况.主要的Sjögren综合征转录基因组序列的测序环RNA 环RNA 是一个环RNA.hsa_circ_0000344 在线阅读在 pSS pSS 中.

更多相关视频

Author Spotlight: Oral Candida Diagnosis to Advance Clinical Treatment Regimen for pSS Patients

Author Spotlight: Oral Candida Diagnosis to Advance Clinical Treatment Regimen for pSS Patients

Published on: March 1, 2024

Author Spotlight: Exploring the Role of Inflammation in the Co-occurrence of Primary Sjogren's Syndrome and Lung Adenocarcinoma

Author Spotlight: Exploring the Role of Inflammation in the Co-occurrence of Primary Sjogren's Syndrome and Lung Adenocarcinoma

Published on: September 20, 2024

相关概念视频

The JAK-STAT Signaling Pathway

The JAK-STAT Signaling Pathway

Several cytokine receptors have tightly bound Janus kinase or JAK proteins attached at their cytosolic tail. Small signaling molecules such as cytokines, growth hormones, or prolactins bind to the cytokine receptors and initiate their dimerization. The dimerization brings the cytosolic JAKs together that trans-phosphorylate and activates each other. The activated JAKs now phosphorylate cytosolic tails of the cytokine receptors, which serve as binding sites for adaptor proteins such as SH2...

Myasthenia Gravis: Diagnostic Tests

Myasthenia Gravis: Diagnostic Tests

Myasthenia gravis is an autoimmune condition affecting neuromuscular transmission, causing generalized weakness in skeletal muscles. Initial diagnoses rely on patients' signs, symptoms, and medical history. The challenge lies in distinguishing myasthenia from other muscular dystrophies. An important diagnostic feature is the significant improvement of symptoms after administering anticholinesterase inhibitors.
The edrophonium test is a diagnostic tool for myasthenia gravis. It involves...

Rheumatic Heart Disease II: Clinical Manifestations and Diagnostic Studies

Rheumatic Heart Disease II: Clinical Manifestations and Diagnostic Studies

The key clinical manifestations of Rheumatic heart disease (RHD) include several distinct cardiac symptoms.Carditis, a hallmark of acute rheumatic fever, involves inflammation of the heart's endocardium, myocardium, and pericardium. Chronic RHD often results from recurrent episodes of carditis. Its symptoms include the following:Murmurs are caused by valvular damage, especially to the mitral and aortic valves. Mitral stenosis or regurgitation is common, with characteristic heart murmurs...