[怀孕期间暴露于非最佳温度和早产之间的关联]
概括
在怀孕期间暴露于极端温度会增加早产风险. 容易感冒的时期是怀孕早期到中期,而热风险是怀孕晚期,特别是与PM2.5污染相结合时.
科学领域:
- 环境健康 环境健康
- 生殖流行病学 生殖流行病学
- 围产儿医学 围产儿医学
背景情况:
- 在怀孕期间暴露于非最佳温度是产生不良分娩结果的潜在危险因素.
- 确定特定的暴露窗口和与环境污染物的相互作用对于有针对性的干预至关重要.
研究的目的:
- 调查非最佳温度暴露与早产风险之间的关联.
- 为了识别易受温度暴露的孕期窗口.
- 分析温度和空气污染物暴露在早产儿之间的相互作用.
主要方法:
- 对1852名孕妇进行了队列研究,将住宅地址与气象数据 (ERA5) 和基于卫星的污染数据联系起来.
- 使用分布式滞后非线性模型和乘法相互作用模型来评估温度效应和与PM2.5.5的相互作用.
- 包括母亲年龄,BMI和社会经济因素在内的混因素经过调整.
主要成果:
- 在1-22周的极低温度 (P1,P5) 和27周和32-36周的极高温度 (P97,P99) 与早产风险增加有关.
- 极低和极高的温度都显示出与PM2.5暴露的多重相互作用.
- 根据母亲的年龄,职业,GDP,怀孕前的BMI和新生儿的性别进行了调整.
结论:
- 怀孕期间非最佳温度暴露与早产风险更高有关.
- 对极度寒冷的敏感窗口是怀孕早期到中期,对于极度热,怀孕晚期.
- 对非最佳温度和PM2.5污染的联合暴露加剧了早产风险.
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